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Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic
The International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP) supported an international panel tasked with reviewing the methodology for clinical trials in spinal cord injury (SCI), andExpand
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Minocycline Treatment Reduces Delayed Oligodendrocyte Death, Attenuates Axonal Dieback, and Improves Functional Outcome after Spinal Cord Injury
Minocycline has been demonstrated to be neuroprotective after spinal cord injury (SCI). However, the cellular consequences of minocycline treatment on the secondary injury response are poorlyExpand
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Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology
Motor and sensory deficits are well-known consequences of spinal cord injury (SCI). During the last decade, a significant number of experimental and clinical studies have focused on the investigationExpand
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Setting the stage for functional repair of spinal cord injuries: a cast of thousands
Here we review mechanisms and molecules that necessitate protection and oppose axonal growth in the injured spinal cord, representing not only a cast of villains but also a company of therapeuticExpand
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Autoradiographic demonstration of the projections from the mesencephalic locomotor region
An autoradiographic tracing technique was used to examine the projections of the classically defined mesencephalic locomotor region (MRL). Injections of [3H]proline and [3H]leucine were made intoExpand
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Modulating astrogliosis after neurotrauma
Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robustExpand
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Localization of a descending pathway in the spinal cord which is necessary for controlled treadmill locomotion
The spinal cord pathways which are important for controlled treadmill locomotion evoked by stimulation of the mesencephalic locomotor region (MLR) were investigated in cats subjected to subtotalExpand
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Minocycline as a Neuroprotective Agent
Several studies have shown that minocycline, a semisynthetic, second-generation tetracycline derivative, is neuroprotective in animal models of central nervous system trauma and severalExpand
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Ontogeny of bipedal locomotion: walking and running in the chick.
1. The purpose of this study was to determine whether the production of an energy‐efficient bipedal walk is an innate attribute of a precocial bird. 2. The locomotor characteristics of hatchlingExpand
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A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo
Bone morphogenetic proteins (BMPs) and their endogenous inhibitors, including noggin, chordin and follistatin, have roles in pattern formation and fate specification of neuronal and glial cellsExpand
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