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Minocycline Treatment Reduces Delayed Oligodendrocyte Death, Attenuates Axonal Dieback, and Improves Functional Outcome after Spinal Cord Injury
Minocycline ameliorates multiple secondary events after SCI, rendering this clinically used drug an attractive candidate for SCI treatment trials.
Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology
The aim of this review is to outline the incidence and pathophysiological mechanisms underlying the orthostatic hypotension that commonly occurs following spinal cord injury and to describe the clinical abnormalities of blood pressure control following SCI.
Modulating astrogliosis after neurotrauma
It is most likely that, to obtain long distance axonal regeneration within the injured adult CNS, a combinatorial approach involving different repair strategies, including but not limited to astrogliosis modulation, will be required.
Setting the stage for functional repair of spinal cord injuries: a cast of thousands
Here we review mechanisms and molecules that necessitate protection and oppose axonal growth in the injured spinal cord, representing not only a cast of villains but also a company of therapeutic
Minocycline as a Neuroprotective Agent
It is suggested that minocycline may inhibit several aspects of the inflammatory response and prevent cell death through the inhibition of the p38 mitogen-activated protein kinase pathway, an important regulator of immune cell function and cell death.
Ontogeny of bipedal locomotion: walking and running in the chick.
The results show that even highly precocial bipeds need to acquire the ability to walk in a controlled and energy efficient manner, although they can innately run as well as an adult.