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Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
Pemphigus vulgaris (PV) is a life-threatening skin disease in which autoantibodies against a keratinocyte cell surface 130 kd glycoprotein, PV antigen (PVA), cause loss of cell-cell adhesion, withExpand
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Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.
This review discusses the autoantibodies in pemphigus vulgaris and pemphigus foliaceus and the clinical and pathological similarities among these forms of pemphigus, bullous impetigo, and theExpand
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Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin
LANGERHANS cells (LC) are the principal accessory cells present in epidermis1. Because LC have limited capacity for self-renewal2, epidermis is continually repopulated by as-yet uncharacterized boneExpand
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Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.
Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PVExpand
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Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia
Abstract Bullous pemphigoid (BP) antigen is a normal basement membrane zone antigen of epidermis and other stratified squamous epithelia. It is defined immunologically by antibodies in the sera ofExpand
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Desmoglein 3 anchors telogen hair in the follicle.
Little is known about the function of desmosomes in the normal structure and function of hair. Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) notExpand
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Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris
In patients with pemphigus vulgaris (PV), autoantibodies against desmoglein 3 (Dsg3) cause loss of cell–cell adhesion of keratinocytes in the basal and immediate suprabasal layers of stratifiedExpand
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A survey of transformation markers in differentiating epidermal cell lines in culture.
Primary mouse epidermal cells underwent spontaneous malignant transformation in culture. TWelve malignant epidermal cell lines were established which produced squamous cell carcinomas in syngeneicExpand
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Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.
Complementary DNA cloning of the 130-kD pemphigus vulgaris (PV) autoantigen (PVA) has indicated that it is a member of the cadherin family of Ca(2+)-dependent cell adhesion molecules. By homologyExpand
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Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: members of a new gene family involved in organization of intermediate filaments.
Desmoplakins (DP) and bullous pemphigoid antigen (BPA) are major plaque components of the desmosome and hemidesmosome, respectively. These cell adhesion structures are both associated intimately withExpand
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