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Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin
It is reported that fresh murine LC express cadherins, and that LC adhere to KC in vitro through E-cadherin, and to begin to elucidate mechanisms involved in LC trafficking, LC-keratinocyte (KC) interactions are characterized.
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.
The clinical and pathological similarities among these forms of pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome are discussed.
Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.
- M. Mahoney, Z. Wang, K. Rothenberger, P. J. Koch, M. Amagai, J. Stanley
- Biology, MedicineThe Journal of clinical investigation
- 15 February 1999
It is suggested that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and it is demonstrated that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.
Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris
It is suggested that pemphigus autoantibodies might interfere directly with such a function of DSG3, and the critical importance of Dsg3 for adhesion in deep stratified squamous epithelia is demonstrated.
Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: members of a new gene family involved in organization of intermediate filaments.
Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia
Desmoglein 3 anchors telogen hair in the follicle.
Desmoglein as a target in skin disease and beyond
The story of desmoglein research illuminates how dermatologic research originally focused on one skin disease, pemphigus, has contributed to understanding biology and pathophysiology of many seemingly unrelated tissues and diseases.
A survey of transformation markers in differentiating epidermal cell lines in culture.
Results indicate that malignant transformation in epidermis is associated with a fundamental alteration in the program of terminal differentiation which allows some cells to escape the proliferative block and cell death which accompanies differentiation in normal keratinocytes.