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Improvement of hepatorenal syndrome with extracorporeal albumin dialysis mars: Results of a prospective, randomized, controlled clinical trial
It is concluded that the removal of albumin‐bound substances with the MARS method can contribute to the treatment of type I HRS.
Albumin dialysis in cirrhosis with superimposed acute liver injury: A prospective, controlled study
ECAD appears to be effective and safe for the short‐term treatment of patients with cirrhosis and superimposed acute injury associated with progressive hyperbilirubinemia and may be useful for increasing survival in such patients awaiting liver transplantation.
Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support.
A new membrane separation system that is nearly impermeable to proteins but enables the exchange of water soluble and protein bound toxins by a special membrane and a recycled protein containing dialysate is described.
Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis
The use of ECAD may be associated with an earlier and more frequent improvement of HE (grade 3/4) and a full assessment of the role of albumin dialysis awaits the results of additional controlled trials.
A new procedure for the removal of protein bound drugs and toxins.
The system effectively removed strongly albumin bound toxins like unconjugated bilirubin or free fatty acids from plasma and blood in vitro and in vivo and therefore could be considered a possible therapeutic means for the treatment of acute liver failure or acute and chronic intoxications with album in bound toxins, e.g., in drug overdose or chronic renal failure.
Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure.
It is concluded that the molecular adsorbent recirculating system can contribute to the treatment of critically ill patients with liver failure and different underlying diseases.
The molecular adsorbents recycling system as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective, randomized, controlled clinical trial, and
In treating liver failure and cholestasis, MARS was associated with hemodynamic stabilization, improvement of hepatic and kidney function, and disappearance of pruritus, and a prospective, randomized, controlled trial of MARS treatment was able to prolong survival time significantly.
A Carrier-Mediated Transport of Toxins in a Hybrid Membrane. Safety Barrier between a Patients Blood and a Bioartificial Liver
  • J. Stange, S. Mitzner
  • Biology, Medicine
    The International journal of artificial organs
  • 1 November 1996
The presented hybrid membrane may be used like an “intellegent membrane” as a safety barrier between the patients blood and cell devices and a significant reduction of protein bound toxins and a transport of metabolically relevant solutes, like amino acids, was shown.
Improvement of multiple organ functions in hepatorenal syndrome during albumin dialysis with the molecular adsorbent recirculating system.
It is concluded that MARS can improve multiple organ functions in patients with HRS and one man underwent successful liver transplantation 18 months after the treatment.
Liver support by extracorporeal blood purification: A clinical observation
It is concluded that in acute excretory failure caused by a chronic liver disease, this treatment provides a therapy option to remove toxins involved in multiorgan dysfunction secondary to liver failure.