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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
TLDR
The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far.
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
TLDR
Computer modeling of agonist binding data with a ternary complex model indicates that the model can fit the data with high accuracy under conditions where the ligand used is either a full or a partial agonist and where the system is altered by the addition of guanine nucleotide or after treatment with group-specific reagents.
Chemokine Receptors in Human Endothelial Cells
TLDR
Exercise of CXCR4 in EC is significant, more so as it and several CC chemokine receptors have been shown to serve as fusion co-receptors along with CD4 during human immunodeficiency virus infection.
Cloning and characterization of a human angiotensin II type 1 receptor.
TLDR
Southern and Northern blot analyses indicated that the cloned receptor is represented as a single copy in the human genome and is expressed in many tissues of different histogenic origin with the exception of brain, where mRNA transcripts were barely detectable.
Pharmacologic and therapeutic applications of alpha 2-adrenoceptor subtypes.
TLDR
In addition to their long-known efficacy in hypertension, iX2-adrenoceptor agonists are now being utilized clinically for several new indications, as well as discrep­ ancies between the subtypes identified using these schemes.
Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway.
TLDR
It is suggested that the G alpha constructs able to complement scg1 can interact with beta gamma to prevent activation of the pathway but are unable to interact with pheromone receptors to activate the pathway.
Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling.
TLDR
The results provide strong evidence at the protein level that thrombin cleaves its receptors at the predicted site, show that receptor activation is necessary for internalization, and suggest that eachThrombin molecule may not activate large numbers of receptors.
Ubiquitin fusion augments the yield of cloned gene products in Escherichia coli.
TLDR
An expression system has been established in Escherichia coli to increase the yield of cloned gene products, where the C terminus of ubiquitin was fused to the Nterminus of unstable or poorly expressed proteins.
Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.
TLDR
The results of these studies demonstrate that hPDE IV activity and high affinity [3H](R)-rolipram binding are properties of the same protein, but they do not provide clear cut evidence linking the binding site with the PDE inhibitory activity of rolipram and related compounds.
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