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Nitric oxide in pancreatic secretion and hormone-induced pancreatitis in rats
It is concluded that NO is involved in the stimulation of pancreatic secretion in vivo and exhibits a beneficial effect on pancreatitis, probably by improving the pancreatic blood flow.
Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases
Evaluating the clinicopathologic profile of GISTs that have KIT exon 13 or exon 17 mutations found that Gastric KITExon 13 mutant GIST's tend to be slightly larger and more aggressive than gastric GIST’s in average, whereas the behavior of small intestinal Gists with KITexon 13 mutations does not differ from other small intestinalGISTs.
Gastrointestinal Stromal Tumors with Internal Tandem Duplications in 3′ End of KIT Juxtamembrane Domain Occur Predominantly in Stomach and Generally Seem to Have a Favorable Course
The great majority of GISTs with ITDs in the 3′ KIT-JM were mitotically inactive tumors occurring predominantly in the stomach and that seemed to have a favorable course, which suggests that presence of these IDTs may define a clinicopathologically favorable subset of Gists.
Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors
It is concluded that presence of homozygous KIT exon 11 mutations is associated with malignant course of disease and should be considered an adverse prognostic marker in GISTs.
KRAS mutation profile in colorectal carcinoma and novel mutation--internal tandem duplication in KRAS.
Oncogenic KRAS mutations are associated with resistance to anti-EGFR therapy in colorectal carcinoma. Since anti-EGFR monoclonal antibodies are employed in clinical practice in advanced colorectal
ALK-positive diffuse large B-cell lymphoma: two more cases and a brief literature review.
Genetic studies showed that the majority of ALK+DLBCL cases are characterized by the clathrin (CLTC)-ALK fusion and in a few cases the NPM-ALK rearrangement has been found.
Prostaglandin protection of the gastric mucosa against alcohol injury--a dynamic time-related process. Role of the mucosal proliferative zone.
The mucosal proliferative zone was severely damaged in controls within the first hour after ethanol administration, whereas 16,16-dimethyl prostaglandin E2 protected the zone from damage and prompt restoration of the surface epithelium and resumption of its barrier and transport functions.
The role of melatonin and L‐tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin
The role of melatonin and L‐tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin is studied.
Vascular and Microvascular Changes—Key Factors in the Development of Acetic Acid‐Induced Gastric Ulcers in Rats
It is concluded that a key feature of acetic acid-induced ulcer formation is the early vascular and microvascular injury, which precedes glandular cell necrosis.
Evaluation of HER2/neu gene amplification in patients with invasive breast carcinoma. Comparison of in situ hybridization methods.
There is no clear answer which method is the best assay to determine HER2 marker status, although the authors present some advantages and disadvantages of all the described techniques and a proposed algorithm for choosing a method for a given laboratory.