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Identification of human brain tumour initiating cells
TLDR
The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Identification of a cancer stem cell in human brain tumors.
TLDR
The identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation is reported.
Erlotinib in lung cancer - molecular and clinical predictors of outcome.
TLDR
Among patients with non-small-cell lung cancer who receive erlotinib, the presence of an EGFR mutation may increase responsiveness to the agent, but it is not indicative of a survival benefit.
Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the
TLDR
37 guideline items address 14 subjects, including 15 recommendations (evidence grade A/B), to use testing for EGFR mutations and ALK fusions to guide patient selection for therapy with an epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) inhibitor in all patients with advanced-stage adenocarcinoma.
Mutations in SUFU predispose to medulloblastoma
TLDR
It is reported that a subset of children with medulloblastoma carry germline and somatic mutations in SUFU (encoding the human suppressor of fused) of the SHH pathway, accompanied by loss of heterozygosity of the wildtype allele.
Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21.
TLDR
EGFR mutations and high copy number are predictive of response to erlotinib and EGFR FISH is the strongest prognostic marker and a significant predictive marker of differential survival benefit from erlot inib.
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
TLDR
TAp73 isoforms exert tumor-suppressive functions and indicate an emerging role for Trp73 in the maintenance of genomic stability, as well as hippocampal dysgenesis.
Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome.
TLDR
It is shown here that the incidence of female monozygotic twins among patients with BWS is dramatically increased over that of the general population, and that KCNQ1OT1 is especially vulnerable to a loss of imprinting event at a critical stage of preimplantation development.
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