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Immunological functions of the pulmonary epithelium.
The mature pulmonary epithelium forms a continuous lining to the airspace. Recent data suggest that this specialized epithelium may also contribute to host defence via interactions with inflammatoryExpand
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Regional distribution of emphysema: correlation of high-resolution CT with pulmonary function tests in unselected smokers.
High-resolution computed tomography (CT) was correlated with pulmonary function tests in the evaluation of regional emphysema in 59 smokers. The lung was divided into upper (above the carinaExpand
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Prostaglandin E(2) inhibits fibroblast chemotaxis.
Fibroblasts are the major source of extracellular connective tissue matrix, and the recruitment, accumulation, and stimulation of these cells are thought to play important roles in both normalExpand
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Pathogenesis of COPD.
Chronic obstructive pulmonary disease (COPD) is characterized and defined by limitation of expiratory airflow. This can result from several types of anatomical lesions, including loss of lung elasticExpand
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Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells.
Ciliary beating is required for the maintenance of lung mucociliary transport. We investigated the role of cyclic nucleotide-dependent protein kinases in stimulating ciliary beat frequency (CBF) inExpand
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Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema.
On the basis of the "protease-antiprotease imbalance" theory for the pathogenesis of pulmonary emphysema, we hypothesized that measurement of elastase burden and antielastase capacity in the alveolarExpand
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Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis.
Cigarette smoking is the most clearly recognized cause of pulmonary emphysema. Since loss of lung tissue, which characterizes emphysema, represents a balance between injury and repair, weExpand
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Cigarette smoke extract inhibits fibroblast-mediated collagen gel contraction.
Cigarette smoking, the major cause of pulmonary emphysema, is characterized by destruction of alveolar walls. Because tissue destruction represents a balance between injury and repair, weExpand
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Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans.
Cardiopulmonary bypass induces an inflammatory state characterized by tumor necrosis factor-alpha release. Integrin CD11b is a neutrophil surface adhesive glycoprotein integrin that is rapidly andExpand
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Cell-matrix and cell-cell interactions modulate apoptosis of bronchial epithelial cells.
Apoptosis is an important process maintaining cell number and tissue structure. To determine whether cell-extracellular matrix (ECM) and cell-cell interactions modulate apoptosis in bronchialExpand
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