Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
- F. Humby, M. Bombardieri, C. Pitzalis
- Biology, MedicinePLoS Medicine
- 1 January 2009
It is demonstrated that FDC+ follicular units invariably express AID and are surrounded by ACPA-producing plasma cells, providing strong evidence that ectopic lymphoid structures in the RA synovium are functional and support autoantibody production.
Malignant lymphoma of mucosa‐associated lymphoid tissue
- P. Isaacson, J. Spencer
- MedicineHistopathology
- 1 May 1987
In this paper their morphological features are reviewed; recent findings based on immunohistochemistry and DNA analysis are presented; and the biological behaviour of these tumours is discussed insofar as they offer insight into mucosal immunological mechanisms.
The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori
- T. Hussell, P. Isaacson, J. Spencer, J. Crabtree
- Medicine, BiologyThe Lancet
- 4 September 1993
Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis.
- S. Hessey, J. Spencer, M. Dixon
- Medicine, BiologyGut
- 1 February 1990
A significant increase in the proportion of attached bacteria in cases showing histological epithelial degeneration, and a significant decrease in cases show intraepithelial polymorph infiltration are found.
Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune…
- M. Bombardieri, F. Barone, C. Pitzalis
- BiologyJournal of Immunology
- 1 October 2007
It is reported that AID retains its exclusive association with numerous, residual GCs in parotid SS-MALT lymphomas, whereas neoplastic marginal zone-like B cells are consistently AID negative, which strongly support the notion that ectopic lymphoid structures in SS-SGs express the molecular machinery to support local autoantibody production and B cell expansion and may play a crucial role toward lymphomagenesis.
Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
- H. Souza, C. Elia, J. Spencer, T. Macdonald
- Medicine, BiologyGut
- 1 December 1999
The expression of MAdCAM-1 and Ox40 ligand on gut endothelial and OX40+ cells is increased in sites of mucosal inflammation in patients with inflammatory bowel disease.
Mouse and human intestinal immunity: same ballpark, different players; different rules, same score
- D. Gibbons, J. Spencer
- BiologyMucosal Immunology
- 12 January 2011
This review will consider general differences in the structure and development of human and mouse mucosal lymphoid microenvironments and then discuss species differences in mucosal B- and T-cell biology that relate to the current concepts of intestinal immune function.
Human gut-associated lymphoid tissues (GALT); diversity, structure, and function
- U. Mörbe, Peter B. Jørgensen, W. Agace
- BiologyMucosal Immunology
- 22 March 2021
The current understanding of human GALT diversity, structure, and composition as well as their potential for regulating intestinal immune responses during homeostasis and inflammatory bowel disease (IBD) are reviewed.
HELICOBACTER PYLORI‐SPECIFIC TUMOUR‐INFILTRATING T CELLS PROVIDE CONTACT DEPENDENT HELP FOR THE GROWTH OF MALIGNANT B CELLS IN LOW‐GRADE GASTRIC LYMPHOMA OF MUCOSA‐ASSOCIATED LYMPHOID TISSUE
- Tracey Hussell, P. Isaacson, J. Crabtree, J. Spencer
- Medicine, BiologyJournal of Pathology
- 1 February 1996
B‐cell proliferation in cases of low‐grade gastric lymphoma of MALT type in vitro in response to H. pylori is suggested to be due to recognition of H.pylori by tumour‐infiltrating T cells, which in turn provide help for tumour cell proliferation.
Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells
- D. Dunn-Walters, P. Isaacson, J. Spencer
- BiologyJournal of Experimental Medicine
- 1 August 1995
These studies provide the first evidence that the human splenic MGZ is a reservoir of memory B cells.
...
...