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International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia
Background HHT is an autosomal dominant disease with an estimated prevalence of at least 1/5000 which can frequently be complicated by the presence of clinically significant arteriovenous… Expand
Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysis.
IMPORTANCE Endovascular intervention for acute ischemic stroke improves revascularization. But trials examining endovascular therapy yielded variable functional outcomes, and the effect of… Expand
Delayed Ipsilateral Parenchymal Hemorrhage Following Flow Diversion for the Treatment of Anterior Circulation Aneurysms
Acute and subacute complications from the use of the Pipeline device are becoming evident. Here, the authors report delayed ipsilateral hemorrhage in 8.5% of patients with anterior circulation… Expand
Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a meta-analysis
- A. Laupacis, Erin Lillie, +7 authors J. Spears
- Canadian Medical Association Journal
- 8 November 2011
Background: It has been proposed by Zamboni and colleagues that multiple sclerosis is caused by chronic cerebrospinal venous insufficiency, a term used to describe ultrasound-detectable abnormalities… Expand
A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
IMPORTANCE Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe… Expand
Canadian Experience with the Pipeline Embolization Device for Repair of Unruptured Intracranial Aneurysms
- C. O’kelly, J. Spears, +6 authors T. Marotta
- American Journal of Neuroradiology
- 1 February 2013
BACKGROUND AND PURPOSE: Flow-diverting stents, such as the PED, have emerged as a novel means of treating complex intracranial aneurysms. This retrospective analysis of the initial Canadian… Expand
Nonaneurysmal perimesencephalic subarachnoid hemorrhage: diagnosis, pathophysiology, clinical characteristics, and long-term outcome.
- A. Kapadia, T. Schweizer, J. Spears, M. Cusimano, R. Macdonald
- World neurosurgery
- 1 December 2014
Patients with nonaneurysmal perimesencephalic subarachnoid hemorrhage (NAPSAH) have no discernible source for the bleeding and generally are considered to have a benign condition. Correctly… Expand
Clinical Prediction Models for Aneurysmal Subarachnoid Hemorrhage: A Systematic Review
BackgroundClinical prediction models can enhance clinical decision-making and research. However, available prediction models in aneurysmal subarachnoid hemorrhage (aSAH) are rarely used. We evaluated… Expand
Predictors of death in pediatric patients requiring cerebrospinal fluid shunts.
OBJECT Despite improved therapeutic strategies and better diagnostic techniques in the management of pediatric hydrocephalus there continues to be a significant mortality rate associated with… Expand
A Discriminative Prediction Model of Neurological Outcome for Patients Undergoing Surgery of Brain Arteriovenous Malformations
Background and Purpose— To develop and validate a discriminative model for predicting neurological morbidity after brain arteriovenous malformation (bAVM) surgery. Methods— Of 233 consecutive,… Expand