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- Publications
- Influence
Argonaute2 Is the Catalytic Engine of Mammalian RNAi
- Jidong Liu, M. Carmell, +6 authors G. Hannon
- Biology, Medicine
- Science
- 3 September 2004
Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) and Argonaute family… Expand
Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome
To equalize X-chromosome dosages between the sexes, the female mammal inactivates one of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression of Xist, a 17-kb noncoding… Expand
Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
- J. Song, S. Smith, G. Hannon, L. Joshua-Tor
- Biology, Medicine
- Science
- 3 September 2004
Argonaute proteins and small interfering RNAs (siRNAs) are the known signature components of the RNA interference effector complex RNA-induced silencing complex (RISC). However, the identity of… Expand
Purified Argonaute2 and an siRNA form recombinant human RISC
- F. Rivas, N. Tolia, +4 authors L. Joshua-Tor
- Biology, Medicine
- Nature Structural &Molecular Biology
- 1 April 2005
Genetic, biochemical and structural studies have implicated Argonaute proteins as the catalytic core of the RNAi effector complex, RISC. Here we show that recombinant, human Argonaute2 can combine… Expand
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes
- J. Song, Jidong Liu, +5 authors L. Joshua-Tor
- Biology, Medicine
- Nature Structural Biology
- 16 November 2003
RISC, the RNA-induced silencing complex, uses short interfering RNAs (siRNAs) or micro RNAs (miRNAs) to select its targets in a sequence-dependent manner. Key RISC components are Argonaute proteins,… Expand
On the Convergent Evolution of Animal Toxins
- M. Dauplais, A. Lecoq, +9 authors A. Ménez
- Biology, Medicine
- The Journal of Biological Chemistry
- 14 February 1997
BgK is a K+ channel-blocking toxin from the sea anemone Bunodosoma granulifera It is a 37-residue protein that adopts a novel fold, as determined by NMR and modeling. An alanine-scanning-based… Expand
Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua.
- E. Kim, Hsiang-Chih Lu, H. Y. Zoghbi, J. Song
- Biology, Medicine
- Genes & development
- 15 March 2013
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by polyglutamine expansion in Ataxin-1 (ATXN1). ATXN1 binds to the transcriptional repressor Capicua… Expand
Argonaute and RNA--getting into the groove.
- J. Song, L. Joshua-Tor
- Biology, Medicine
- Current opinion in structural biology
- 1 February 2006
RNAi has made an enormous impact on biology in a very short period of time. It became an extraordinarily useful and simple tool for gene silencing, even as its fascinating mechanism was gradually… Expand
Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs.
- M. Jo, Soochul Shin, Seung-Ryoung Jung, E. Kim, J. Song, S. Hohng
- Biology, Medicine
- Molecular cell
- 2 July 2015
Argonaute is a key enzyme of various RNA silencing pathways. We use single-molecule fluorescence measurements to characterize the reaction mechanisms of the core-RISC (RNA-induced silencing complex)… Expand
Huntingtin facilitates polycomb repressive complex 2
- I. S. Seong, J. Woda, +11 authors M. MacDonald
- Biology, Medicine
- Human molecular genetics
- 23 November 2009
Huntington's disease (HD) is caused by expansion of the polymorphic polyglutamine segment in the huntingtin protein. Full-length huntingtin is thought to be a predominant HEAT repeat α-solenoid,… Expand