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Serum CBG, free and total cortisol and circadian patterns of adrenal function in normal pregnancy.
Parameters of cortisol metabolism were studied in pregnancy and early post partum and in non pregnant women. Total serum cortisol was measured by a specific radioimmunoassay and its unbound- andExpand
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Adrenocortical hormones, ageing and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11-deoxycorticosterone, total and free cortisol and urinary corticosteroids.
The circannual rhythms of plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC), total and free cortisol have been documented on a circadian basis in January, March, June and October in seven youngExpand
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Heterogeneous IgG subclass distribution of islet cell antibodies.
Islet cell antibodies (ICA)-IgG are the serological marker of type 1 diabetes, an organ-specific autoimmune disease. A proportion of patients also have thyro-gastric autoimmunity, implying a broaderExpand
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Radioimmunoassay of corticosterone, cortisol and cortisone: their application to human cord and maternal plasma.
Abstract A critical analysis of the applicability of corticosterone, cortisone and cortisol radioimmunoassays in human plasma is presented. Rabbits immunized with corticosteroid-3-CMO-BSA conjugatesExpand
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Pancreatic hormone receptors on islet cells.
To assess whether islet cells are equipped with recognition units which allow an intra-islet regulation via released hormones, the presence of insulin and glucagon receptors is investigated onExpand
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Superiority of Radiobinding Assay Over ELISA for Detection of IAAs in Newly Diagnosed Type I Diabetic Children
Objective Liquid- or solid-phase assays have been used for insulin autoantibody (IAA) determination, and the method of IAA measurement has not been standardized. Research Design and Methods IAAs wereExpand
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Advantages and pitfalls of radioimmune and enzyme linked immunosorbent assays of insulin antibodies
SummaryHuman sera were tested for insulin antibodies by fluid and solid phase assays. Radioimmune titres determined with 125-I Tyr A14 insulin were not correlated with those obtained using insulinExpand
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Abnormal Circulating Pancreatic Enzyme Activities in More than Twenty‐Five Percent of Recent‐Onset Insulin‐Dependent Diabetic Patients: Association of Hyperlipasemia with High‐Titer Islet Cell
Pancreatic amylase and lipase activities were measured in sera of 307 Caucasian insulin-dependent diabetes mellitus patients (IDDM) at clinical onset, 303 nondiabetic siblings of registered patients,Expand
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Highly specific radioimmunoassay for human insulin based on immune exclusion of all insulin precursors.
We describe a rapid and simple insulin RIA in which proinsulin and conversion intermediates do not interfere. Three monoclonal antibodies (S1, S2, and S53) were selected for their specificityExpand
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First direct assay for intact human proinsulin.
We describe a sensitive two-site sandwich enzyme-linked immunosorbent assay for the measurement of intact human proinsulin in 100 microL of serum or plasma. The assay is based on the use of twoExpand
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