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The oxidative metabolism of catecholamines in the brain: a review.
The strong evidence that the authors now have that the oxidative pathway of metabolism of the catecholamines, dopamine and norepinephrine via their respective quinones via the chemical structure of neuromelanin and advanced mass spectrometry techniques occurs in vivo in the brain is summarized. Expand
Beyond Reductionism New Perspectives In The Life Sciences
Bring home now the book enPDFd beyond reductionism new perspectives in the life sciences the alpbach symposium 1968 to be your sources when going to read. It can be your new collection to not onlyExpand
Redox mechanisms at the glutamate synapse and their significance: a review.
  • J. Smythies
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1 April 1999
The hypothesis is presented that the growth or pruning of the synaptic spine is controlled in part by the balance in the synapse between neurodestructive pro-oxidants and neuroprotective antioxidants and catecholamines, in particular dopamine, related to its role in reinforcement signalling. Expand
Space, Time and Consciousness
This paper describes a new theory of consciousness based on previous work by C.D. Broad, H.H. Price, Andrei Linde and others. This hypothesis states that the Universe consists of three fundamentalExpand
Schizophrenia; a new approach. II. Result of a year's research.
It is shown that adrenochrome, a derivative of adrenaline, has psychological properties similar to those of mescaline and lysergic acid, and is the first time that a substance which probably occurs in the human body has been found to be active in this way. Expand
The stroboscopic patterns. II. The phenomenology of the bright phase and after-images.
  • J. Smythies
  • Psychology, Medicine
  • British journal of psychology
  • 1 November 1959
A detailed study has been made of the bright phase patterns of Brown & Gebhard (1948) produced by looking at a uniform flickering field by investigating the types of movement encountered and the effect of varying a number of parameters. Expand
On the function of neuromelanin
  • J. Smythies
  • Chemistry
  • Proceedings of the Royal Society of London…
  • 22 April 1996
The hypothesis is presented, based on the chemical structure of neuromelanin, that one of its functions in the catecholamine neurons in the brain is to protect the cell against toxic quinones (suchExpand
A New Hallucinogen: 3,4,5-Trimethoxyphenyl-ß-Aminopropane
1. The structural formula of TMA (trimethoxyamphetamine) lies between those of mescaline and amphetamine. It is nontoxic to humans in doses up to 2.0mgm./kgm. of body weight. In mice it produced noExpand