P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study
Expert opinion on the cough hypersensitivity syndrome in respiratory medicine
It is considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area.
Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report.
A comparison of objective and subjective measures of cough in asthma.
Objective cough frequency in Idiopathic Pulmonary Fibrosis
This study confirms objectively that cough is a major, very distressing and disabling symptom in IPF patients and strong correlations between objective cough counts and cough related quality of life measures suggest that in IPf patient's, perception of cough frequency is very accurate.
High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.
The very low organism burdens of fungi causing infection have previously prevented direct culture and detection of antifungal resistance in clinical samples, and these findings have major implications for the sustainability of triazoles for human antIFungal therapy.
Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection.
- R. Stovold, I. Forrest, C. Ward
- Medicine, BiologyAmerican Journal of Respiratory and Critical Care…
- 15 June 2007
Elevated levels of pepsin, a biomarker of gastric aspiration, are consistently identified in the BAL of lung allografts, providing further evidence supporting the possible role of aspiration in the development of overall allografted injury.
Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?
- S. Decalmer, D. Webster, A. Kelsall, K. Mcguinness, A. Woodcock, J. Smith
- Medicine, PsychologyThorax
- 1 April 2007
Cough-related quality of life (LCQ) is most strongly related to objectively counted cough, and may be a useful adjunct to objective measures in the assessment of cough.
Targeting TRP channels for chronic cough: from bench to bedside
- S. Bonvini, M. Birrell, J. Smith, M. Belvisi
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 10 January 2015
This review will cover the current understanding of the role of the TRP family of ion channels in the activation of airway sensory nerves and cough, focusing on four members, transient receptor potential vanilloid (TRPV) 1, transient receptors potential ankyrin (TRPA)1, TRPV4, and transient receptor Potential melastatin (TRPM) 8 as these represent the channels where most information has been gathered with relevance to the airways.