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Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus.
Rearrangements of the ret oncogene were investigated in papillary thyroid carcinomas (PTC) from 51 Belarussian children with a mean age of 3 years at the time of the Chernobyl radiation accident. ForExpand
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Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery. Here we sequence exomes of 31 tumours and decipherExpand
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Genomic Alterations and Allelic Imbalances Are Strong Prognostic Predictors in Osteosarcoma
Purpose: Osteosarcoma, the most common primary malignant tumor of the bone, is characterized by complex karyotypes with numerous structural and numerical alterations. Despite attempts to establishExpand
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Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma – reasons and consequences
Osteosarcomas (OS) are aggressive bone tumors characterized by complex karyotypes with highly variable structural and numerical chromosomal aberrations. Although several genes and pathways commonlyExpand
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How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation
TLDR
We proposed a model of OS cell proliferation which is primarily co-regulated through the interactions of the mentioned microRNA and TF combinations. Expand
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Expression profiling identifies genes that predict recurrence of breast cancer after adjuvant CMF-based chemotherapy
Cyclophosphamide, methotrexate and 5-fluorouracile (CMF)-based chemotherapy for adjuvant treatment of breast cancer reduces the risk of relapse. In this exploratory study, we tested the feasibilityExpand
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TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
Somatic mutations of TP53 are among the most common in cancer and germline mutations of TP53 (usually missense) can cause Li-Fraumeni syndrome (LFS). Recently, recurrent genomic rearrangements inExpand
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Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma
Hematogenous spread determines the outcome of osteosarcoma (OS) patients, but the pathogenesis of developing metastatic disease is still unclear. Chemokines are critical regulators of cellExpand
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Osteosarcomas of the jaws differ from their peripheral counterparts and require a distinct treatment approach. Experiences from the DOESAK Registry.
OBJECTIVE We aim to emphasize crucial differences between osteosarcomas of the jaws (OSj) and those of the peripheral skeleton (OSp) and to question current therapeutic concepts in presenting aExpand
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Structuring osteosarcoma knowledge: an osteosarcoma-gene association database based on literature mining and manual annotation
TLDR
Osteosarcoma (OS) is the most common primary bone cancer exhibiting high genomic instability. Expand
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