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Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions.
- A. Ashimoto, C. Chen, I. Bakker, J. Slots
- Medicine, BiologyOral microbiology and immunology
- 1 August 1996
This study demonstrated the utility of a 16S rRNA-based PCR detection method for identifying important subgingival microorganisms and indicated a strong association between the study species and periodontitis.
Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment.
Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease
In subjects infected with A. actinomycetemcomitans, serum antibodies were detected to the serotype antigens, indicating that these antigen may play a role in the pathogenesis of periodontal disease.
Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation.
A. actinomycetemcomitans was on average recovered in about fivefold-higher numbers from infected deep periodontal pockets than from infected normal subgingival areas.
Selection of antimicrobial agents in periodontal therapy.
- J. Slots
- MedicineJournal of periodontal research
- 1 October 2002
periodontal treatment that includes a battery of professionally and patient-administered antimicrobial agents (properly prescribed systemic antibiotics, povidone-iodine and sodium hypochlorite subgingival irrigants, and chlorhexidine mouthrinse) is recommended.
Detection of human viruses in periodontal pockets using polymerase chain reaction.
It is demonstrated that human viruses may occur in periodontitis lesions with relatively high prevalence and the pathogenetic significance of human viruses in destructive periodontal disease needs to be determined.
Actinobacillus actinomycetemcomitans in human periodontal disease. Prevalence in patient groups and distribution of biotypes and serotypes within families.
The hypothesis that A actinomycetemcomitans is an etiologic agent in this periodontal disease supported by the high prevalence in the subgingival plaque of localized juvenile periodontitis patients, compared to the much lower prevalence in other patient groups.
Antibiotics in periodontal therapy: advantages and disadvantages.
A review of published papers reveals that appropriate systemic antibiotic therapy may enhance healing in patients with recent or high risk of periodontal breakdown and several promising antimicrobial agents for periodontitis treatment need testing in placebo-controlled, double-blind, randomized clinical trials.
Mammalian viruses in human periodontitis.
The role and importance of HCMV and other mammalian viruses in the initiation and progression of destructive periodontal disease merits further investigation.
Actinobacillus actinomycetemcomitans genotypes in relation to serotypes and periodontal status.
A major genetic dissimilarity between A. actinomycetemcomitans serotypes was revealed and a relationship between some A.Actinobacillian clones and periodontal disease was suggested.