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Identification of a Novel Fimbrial Gene Cluster Related to Long Polar Fimbriae in Locus of Enterocyte Effacement-Negative Strains of Enterohemorrhagic Escherichia coli
TLDR
Deletion of the putative major fimbrial subunit gene, lpfA, from EHEC O113:H21 resulted in decreased adherence of this strain to epithelial cells, suggesting that l pfO113 may function as an adhesin in LEE-negative isolates of EH EC. Expand
The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65
TLDR
Overall the data show that EPEC and Shigella have evolved similar T3SS-dependent means to manipulate host inflammatory pathways by interfering with the activation of selected host transcriptional regulators. Expand
Contribution of Efa1/LifA to the adherence of enteropathogenic Escherichia coli to epithelial cells.
TLDR
The data suggest that Efa1 has host cell binding activity, at least in tissue culture, and that it is produced during infection, suggesting that EFA1 may play a direct role in the pathogenesis of infections caused by A/E pathogens. Expand
Transfer Region of pO113 from Enterohemorrhagic Escherichia coli: Similarity with R64 and Identification of a Novel Plasmid-Encoded Autotransporter, EpeA
TLDR
The pO113 transfer region encoded a novel high-molecular-weight serine protease autotransporter of Enterobacteriaceae (SPATE) protein, termed EpeA, which exhibited protease activity and mucinase activity, but expression was not associated with a cytopathic effect on epithelial cells. Expand
Shiga toxin-producing Escherichia coli strains negative for locus of enterocyte effacement.
TLDR
Comparison of the genetic composition of the virulence plasmids of STEC pO113 and pO157 from LEE-negative andLEE-positive STEC strains showed several clonal groups, suggesting that pathogenic L EE-negative STEC has emerged several times throughout its evolution. Expand
Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens
TLDR
Virulence studies carried out using a mouse model implicated the virS gene in the pathogenesis of histotoxic C. perfringens infections and concluded that a two‐component sensor regulator system that activated the expression of a number of extracellular toxins and enzymes involved In virulence had been cloned and sequenced. Expand
Shiga Toxin–producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement
The ehx plasmids of these strains are highly related, which suggests acquisition of the large plasmid was central to the strains’ emergence.
The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of
TLDR
The complete nucleotide sequence and mechanism of action of the tetracycline‐resistance determinant Tet P, from Clostridium perfringens has been determined and it is proposed that tetB(P) evolved from the conjugative transfer into C. perfrings of a fer (M)‐like gene from another bacterium. Expand
Sel1 Repeat Protein LpnE Is a Legionella pneumophila Virulence Determinant That Influences Vacuolar Trafficking
TLDR
It is found that the role of LpnE in host cell invasion is dependent on the eight SLR regions of the protein, and the importance of theSLR regions to L. pneumophila virulence is defined. Expand
Contribution of Long Polar Fimbriae to the Virulence of Rabbit-Specific Enteropathogenic Escherichia coli
TLDR
It is suggested that lpfR141 contributes to the early stages of REPEC-mediated disease and that this is important for the development of severe diarrhea in susceptible animals. Expand
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