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Ketamine – More mechanisms of action than just NMDA blockade
Ketamine's effects in chronic pain, and as an antidepressant, far outlast the actual drug levels, and are probably mediated by a secondary increase in structural synaptic connectivity that is mediated by an neuronal response to the ketamine-induced hyper-glutamatergic state. Expand
Caregiver Burden During the Year Following Severe Traumatic Brain Injury
- N. Marsh, D. Kersel, Jack A Havill, J. Sleigh
- Psychology, Medicine
- Journal of clinical and experimental…
- 1 June 2002
It appears that the impact on caregivers of physical impairment is comparatively short-lived and that caregivers learn some practical ways to manage the behavioural problems of the people with TBI, but over time the person with TBO's behavioural and cognitive problems begins to play a larger role in the level of distress experienced by the caregiver. Expand
Permutation entropy of the electroencephalogram: a measure of anaesthetic drug effect.
PE of the EEG shows promise as a simple measure of GABAergic anaesthetic drug effect as it reliably tracked the anaesthetic-related EEG changes, namely loss of high frequencies, spindle-like waves, and delta waves. Expand
The Howling Cortex: Seizures and General Anesthetic Drugs
On the basis of applied neuropharmacology, prevention of anesthetic-drug related seizures would include avoiding sevoflurane and etomidate, considering prophylaxis with adjunctive benzodiazepines (&agr;-subunit GABAA agonists), or drugs that impair calcium entry into neurons, and using electroencephalogram monitoring to detect early signs of cortical instability and epileptiform activity. Expand
Caregiver burden at 1 year following severe traumatic brain injury.
Results from a regression analysis indicated that the person with TBI's physical impairment, number of behavioural problems, and social isolation were the strongest predictors of caregiver burden. Expand
Practical Use of the Raw Electroencephalogram Waveform During General Anesthesia: The Art and Science
This tutorial describes, and gives examples of, the typical EEG features of adequate general anesthesia, effects of noxious stimulation, and adjunctive drugs, and includes real examples of clinical problem-solving processes. Expand
Theoretical electroencephalogram stationary spectrum for a white-noise-driven cortex: evidence for a general anesthetic-induced phase transition.
- M. Steyn-Ross, D. Steyn-Ross, J. Sleigh, D. Liley
- Medicine, Physics
- Physical review. E, Statistical physics, plasmas…
- 1 December 1999
A model for the dynamics of a cerebral cortex in which inputs to neuronal assemblies are treated as random Gaussian fluctuations about a mean value is presented, suggesting the existence of phase transitions in the cortex. Expand
Comparison of bispectral index, 95% spectral edge frequency and approximate entropy of the EEG, with changes in heart rate variability during induction of general anaesthesia.
BIS had the best predictive power, with a sensitivity of 97.3%, specificity 94.4%, positive predictive value 94.7% and negative predictive value 97.1%. Expand
Caregiver burden at 6 months following severe traumatic brain injury.
It is suggested that the presence of behavioural problems in the person with the TBI that has the most severe and pervasive impact on all aspects of caregiver functioning be taken into account when providing rehabilitation services to people with TBI and their families. Expand
The Sleep Cycle Modelled as a Cortical Phase Transition
- D. Steyn-Ross, M. Steyn-Ross, J. Sleigh, M. Wilson, I. Gillies, J. J. Wright
- Chemistry, Medicine
- Journal of biological physics
- 1 December 2005
It is argued that the change from slow-wave sleep (SWS) to rapid-eye-movement (REM) sleep can be understood as a first-order phase transition from a low-firing, coherent state to a high-f firing, desychronized cortical state. Expand