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Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures.
- M. Gutt, C. L. Davis, +6 authors J. Marks
- Diabetes research and clinical practice
- 1 March 2000
The purpose of this study was to explore possible calculations using oral glucose tolerance test (OGTT) values in order to develop a simple measure of insulin sensitivity. We devised a formula for an… Expand
Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials
Diabetes is defined by its association with hyperglycemia-specific microvascular complications; however, it also imparts a two- to fourfold risk of cardiovascular disease (CVD). Although… Expand
Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.
OBJECTIVE This randomized, double-masked, placebo-controlled clinical trial tested whether oral insulin administration could delay or prevent type 1 diabetes in nondiabetic relatives at risk for… Expand
Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial.
OBJECTIVE Despite the demonstrated benefits of glycemic control, patient acceptance of basal/bolus insulin therapy for type 1 diabetes has been slow. We investigated whether a basal/bolus insulin… Expand
Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: a randomized controlled trial.
- B. Hurwitz, Johanna R Klaus, +8 authors N. Schneiderman
- Archives of internal medicine
- 22 January 2007
BACKGROUND Despite findings that selenium supplementation may improve immune functioning, definitive evidence of its impact on human immunodeficiency virus (HIV) disease severity is lacking. … Expand
Practical recommendations for the management of diabetes in patients with COVID-19
- S. Bornstein, F. Rubino, +17 authors B. Ludwig
- The Lancet Diabetes & Endocrinology
- 23 April 2020
Summary Diabetes is one of the most important comorbidities linked to the severity of all three known human pathogenic coronavirus infections, including severe acute respiratory syndrome… Expand
Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association
Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but… Expand
Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomised proof-of-concept study
- J. Skyler, W. Cefalu, I. Kourides, W. Landschulz, for The Inhaled Insulin Phase II Study Group
- The Lancet
- 3 February 2001
BACKGROUND Effective glycaemic control in type 1 diabetes mellitus usually requires two or more insulin injections daily. Inhaled intrapulmonary delivery of insulin offers a potential new way to… Expand
Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1
OBJECTIVE There is limited information from large-scale prospective studies regarding the prediction of type 1 diabetes by specific types of pancreatic islet autoantibodies, either alone or in… Expand
High-dose insulin therapy: is it time for U-500 insulin?
- W. Lane, E. Cochran, +4 authors J. Skyler
- Endocrine practice : official journal of the…
- 11 February 2009
OBJECTIVE To provide an overview of U-500 regular insulin action, review published clinical studies with U-500 regular insulin, and offer guidance to practicing endocrinologists for identifying… Expand