• Publications
  • Influence
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptiveExpand
  • 963
  • 136
  • PDF
A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
Nef, a approximately 200 residue multifunctional regulatory protein of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV), interacts with components of host cell signalExpand
  • 242
  • 32
  • PDF
Lentiviral Vpx Accessory Factor Targets VprBP/DCAF1 Substrate Adaptor for Cullin 4 E3 Ubiquitin Ligase to Enable Macrophage Infection
Vpx is a small virion-associated adaptor protein encoded by viruses of the HIV-2/SIVsm lineage of primate lentiviruses that enables these viruses to transduce monocyte-derived cells. This probablyExpand
  • 198
  • 28
  • PDF
Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle
The replication of viruses depends on the cell cycle status of the infected cells. Viruses have evolved functions that alleviate restrictions imposed on their replication by the host. Vpr, anExpand
  • 187
  • 21
  • PDF
HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1*
Background: Human SAMHD1 protein restricts HIV/SIV infection of myeloid cells and is targeted for proteasomal degradation by HIV-2 Vpx protein. Results: Vpx binds the divergent C terminus of humanExpand
  • 146
  • 14
  • PDF
Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS
ABSTRACT The human immunodeficiency virus type 1 (HIV-1) Nef protein has several independent functions that might contribute to efficient viral replication in vivo. Since HIV-1 adapts rapidly to itsExpand
  • 152
  • 12
CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.
PCR was used to clone isolates of the human immunodeficiency virus type 1 (HIV-1) nef gene directly from peripheral blood leukocytes of HIV-1-infected individuals. A transient expression system withExpand
  • 169
  • 9
  • PDF
HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis
The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increaseExpand
  • 120
  • 8
  • PDF
Mechanism of Allosteric Activation of SAMHD1 by dGTP
  • X. Ji, Y. Wu, +8 authors Y. Xiong
  • Chemistry, Medicine
  • Nature Structural &Molecular Biology
  • 20 October 2013
SAMHD1, a dNTP triphosphohydrolase (dNTPase), has a key role in human innate immunity. It inhibits infection of blood cells by retroviruses, including HIV, and prevents the development of theExpand
  • 101
  • 8
Making sense out of LINES: long interspersed repeat sequences in mammalian genomes
Abstract The highly repeated DNA sequences that are dispersed in mammalian genomes have seemed hopelessly complex. Because of the high copy-numbers of family members (10 4 to more than 10 5 ) and theExpand
  • 138
  • 7