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Enamel Formation and Amelogenesis Imperfecta
TLDR
The essential elements of dental enamel formation are reviewed and the results of genetic analyses that have identified disease-causing mutations in genes encoding enamel matrix proteins in the etiology of isolated AI are identified. Expand
Functions of KLK4 and MMP-20 in dental enamel formation
TLDR
The principle functions of MMP-20 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins. Expand
Hereditary Dentin Defects
TLDR
This review discusses the development of the dentin extracellular matrix in the context of its evolution, and discusses the phenotypes and clinical classifications of isolated hereditary defects of tooth dentin in thecontext of recent genetic data respecting their genetic etiologies. Expand
ENAM Mutations in Autosomal-dominant Amelogenesis Imperfecta
TLDR
To improve the understanding of the roles of enamelin in normal enamel formation, and to gain information related to possible genotype/phenotype correlations, 2 ENAM mutations in kindreds with hypoplastic ADAI, 1 novel and 1 previously identified, are identified, and the resulting enamel phenotypes are characterized. Expand
Dentin Sialophosphoprotein Is Processed by MMP-2 and MMP-20 in Vitro and in Vivo*
TLDR
Exact correspondence between DSPP cleavage sites that occur in vivo and those generated in vitro demonstrates that M MP-2 and MMP-20 process D SPP into smaller subunits in the dentin matrix during odontogenesis. Expand
Enamel Defects and Ameloblast-specific Expression in Enam Knock-out/lacZ Knock-in Mice*
TLDR
Ameloblast-specific expression of enamelin is demonstrated and it is revealed that enamin is essential for proper enamel matrix organization and mineralization. Expand
Hypomaturation Enamel Defects in Klk4 Knockout/LacZ Knockin Mice*
TLDR
Results demonstrate that Klk4 is essential for the removal of enamel proteins and the proper maturation ofEnamel crystals and an important finding was that individual enamel crystallites of erupted teeth failed to grow together, interlock, and function as a unit. Expand
Regulation of Dental Enamel Shape and Hardness
TLDR
The growth parameters that determine the shape of the enamel crown as well as the mechanisms of enamel appositional growth and maturation are reviewed. Expand
FAM20A Mutations Can Cause Enamel-Renal Syndrome (ERS)
TLDR
FAM20A, which has a kinase homology domain and localizes to the Golgi, is a putative Golgi kinase that plays a significant role in the regulation of biomineralization processes, and that mutations in FAM20A cause both AIGFS and ERS. Expand
Enamelysin (Matrix Metalloproteinase 20)-deficient Mice Display an Amelogenesis Imperfecta Phenotype*
TLDR
It is demonstrated that enamelysin activity is essential for proper enamel development and is likely an important amelogenin-processing enzyme. Expand
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