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Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary dysfunction, resulting in oedema formation and haemorrhagic conversion. There are substantial gaps in understandingExpand
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Cytotoxic edema: mechanisms of pathological cell swelling.
Cerebral edema is caused by a variety of pathological conditions that affect the brain. It is associated with two separate pathophysiological processes with distinct molecular and physiologicalExpand
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Newly expressed SUR1-regulated NCCa-ATP channel mediates cerebral edema after ischemic stroke
Pathological conditions in the central nervous system, including stroke and trauma, are often exacerbated by cerebral edema. We recently identified a nonselective cation channel, the NCCa-ATPExpand
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Molecular pathophysiology of cerebral edema
Advancements in molecular biology have led to a greater understanding of the individual proteins responsible for generating cerebral edema. In large part, the study of cerebral edema is the study ofExpand
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Sulfonylurea receptor 1 in central nervous system injury: a focused review
The sulfonylurea receptor 1 (Sur1)-regulated NCCa-ATP channel is a nonselective cation channel that is regulated by intracellular calcium and adenosine triphosphate. The channel is not constitutivelyExpand
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Cavernous angioma: a review of 126 collected and 12 new clinical cases.
The histopathological, clinical, and radiological features of the intracranial cavernous angioma are reviewed, based on an analysis of 138 symptomatic, histologically verified cases. Twelve of theExpand
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Hemorrhagic progression of a contusion after traumatic brain injury: a review.
The magnitude of damage to cerebral tissues following head trauma is determined by the primary injury, caused by the kinetic energy delivered at the time of impact, plus numerous secondary injuryExpand
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Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury.
Acute spinal cord injury (SCI) causes progressive hemorrhagic necrosis (PHN), a poorly understood pathological process characterized by hemorrhage and necrosis that leads to devastating loss ofExpand
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Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport.
The brain achieves homeostasis of its intracellular and extracellular fluids by precisely regulating the transport of solute and water across its major cellular barriers: endothelia of theExpand
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Novel model of frontal impact closed head injury in the rat.
Frontal impact, closed head trauma is a frequent cause of traumatic brain injury (TBI) in motor vehicle and sports accidents. Diffuse axonal injury (DAI) is common in humans and experimental animals,Expand
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