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S-2-hydroxyglutarate regulates CD 8 + T-lymphocyte fate
In response to T-cell receptor (TCR) triggering, quiescent CD8+ T lymphocytes transition to a proliferative effector state. During this response, memory CD8+ T lymphocytes form and can persist for
The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
S-2-hydroxyglutarate acts as an immunometabolite that links environmental context, through a metabolic–epigenetic axis, to immune fate and function and greatly enhances the in vivo proliferation, persistence and anti-tumour capacity of adoptively transferred CD8+ T cells.
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
It is shown here that FIH loss increases oxidative metabolism, while also increasing glycolytic capacity, and that this gives rise to an increase in oxygen consumption, and it is shown that the loss of FIH acts to accelerate the cellular metabolic response to hypoxia.
A whiter shade of gray: HIF and coordination of angiogenesis with postnatal myelination.
It is shown that hypoxia-inducible factors and Wnt7a/7b act in developing white matter, promoting angiogenesis in anticipation of the metabolic demands of oligogenesis, before finally allowing precursor differentiation.
Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
An experimental strategy is generated whereby the effect of microvascular occlusion in metastatic efficiency is modelled by using inert microbeads to obstruct lung microvasculature before, during and after intravenous tumour cell injection to improve understanding of thrombosis-associated tumorigenesis and its treatment.
The determinants of transverse tubular volume in resting skeletal muscle
  • J. Sim, J. Fraser
  • Chemistry, Medicine
    The Journal of physiology
  • 4 November 2014
A computer model is used to determine that resting t‐tubule volume is maintained by active ion cycling between the extracellular fluid, muscle cell and t‐ Tubules, providing a framework for understanding the role of the t‐system in muscle physiology and pathology.
Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress.
A structural component of lipid droplets is markedly induced in pseudohypoxic renal tumors, where it maintains endoplasmic reticulum homeostasis and is therefore an attractive therapeutic target.
Abstract A19: Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors
The importance of microthrombosis in a novel model of metastasis and the essential role of the myeloid cell-specific HIFα response in mediating this process are demonstrated.