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Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinct… Expand
Comparative Genomics of Trypanosomatid Parasitic Protozoa
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed… Expand
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
The human malaria parasite Plasmodium vivax is responsible for 25–40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating… Expand
Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus
We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri… Expand
Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.
- S. Takala-Harrison, Christopher G. Jacob, +42 authors C. Plowe
- Biology, Medicine
- The Journal of infectious diseases
- 1 March 2015
BACKGROUND The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13… Expand
Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia
- S. Takala-Harrison, T. Clark, +36 authors C. Plowe
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 17 December 2012
The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination. Identification of the genetic basis of resistance… Expand
Horizontal transfer and selection in the evolution of P elements.
The roles of selection and horizontal transfer in the evolution of the canonical subfamily of P: elements were studied in the saltans and willistoni species groups of the genus Drosophila (subgenus… Expand
Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes
We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene… Expand
Intron gain and loss in segmentally duplicated genes in rice
BackgroundIntrons are under less selection pressure than exons, and consequently, intronic sequences have a higher rate of gain and loss than exons. In a number of plant species, a large portion of… Expand
Factors that affect the horizontal transfer of transposable elements.
Transposable elements are characterized by their ability to spread within a host genome. Many are also capable of crossing species boundaries to enter new genomes, a process known as horizontal… Expand