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The parasitic ciliate Ichthyophthirius multifiliis induces expression of immune relevant genes in rainbow trout, Oncorhynchus mykiss (Walbaum).
Data suggest that complement is involved in immune reactions against I. multifiliis and that mucosal antibodies might be produced at the site of infection, as well as in the lymphoid organs. Expand
Expression of pro-inflammatory cytokines in rainbow trout (Oncorhynchus mykiss) during an infection with Ichthyophthirius multifiliis.
The present study shows that the pro-inflammatory cytokines interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha), the chemokine interLEukin 8 ( IL-8) and the type II IL-1 receptor (il-1RII) are expressed in rainbow trout during an infection. Expand
Host responses against the fish parasitizing ciliate Ichthyophthirius multifiliis.
- K. Buchmann, J. Sigh, C. V. Nielsen, M. Dalgaard
- Biology, Medicine
- Veterinary parasitology
- 12 September 2001
Both bath and injection vaccination using live or killed Tetrahymena has been reported to offer treated fish a certain level of protection, which could be explained by non-specific reactions and the efficacy and duration of this vaccination type should be further evaluated. Expand
Comparison of immobilization assays and enzyme‐linked immunosorbent assays for detection of rainbow trout antibody‐titres against Ichthyophthirius multifiliis Fouquet, 1876
Streptococcus pneumoniae: proteomics of surface proteins for vaccine development.
- C. Morsczeck, T. Prokhorova, +8 authors P. Schrotz-King
- Biology, Medicine
- Clinical microbiology and infection : the…
Two candidate proteins, the putative lipoate protein ligase (Lpl) and the ClpP protease, resulted in a reduced CFU titre and a trend towards reduced mortality in an animal sepsis model for investigating new S. pneumoniae protein vaccines. Expand
Skin expression of IL-1beta in East Atlantic salmon, Salmo salar L., highly susceptible to Gyrodactylus salaris infection is enhanced compared to a low susceptibility Baltic stock.
Production of acylated homoserine lactones by different serotypes of Vibrio anguillarum both in culture and during infection of rainbow trout.
- C. Buch, J. Sigh, J. Nielsen, J. L. Larsen, L. Gram
- Biology, Medicine
- Systematic and applied microbiology
The data show that AHLs are produced by almost all V. anguillarum strains and that no clear pattern relating AHL production to disease or virulence appear. Expand
Partial cross protection against Ichthyophthirius multifiliis in Gyrodactylus derjavini immunized rainbow trout.
Fish partly immune to the ectoparasitic monogenean G. derjavini became less infected and experienced lower mortality than naive fish when exposed to I. multifiliis infections, suggesting that non-specific factors including complement could be partly responsible for the host response against infections with this ciliate. Expand
Concizumab, an anti‐tissue factor pathway inhibitor antibody, induces increased thrombin generation in plasma from haemophilia patients and healthy subjects measured by the thrombin generation assay
- E. K. Waters, J. Sigh, U. Friedrich, I. Hilden, B. Sørensen
- Haemophilia : the official journal of the World…
- 1 September 2017
It is investigated how concizumab affects thrombin generation following ex vivo spiking in plasma from haemophilia patients using the TGA, and if the assay can detect the effect of multiple s.c. concIZumab doses in healthy subjects. Expand
Associations between epidermal thionin-positive cells and skin parasitic infections in brown trout Salmo trutta.
It was shown that the metachromatic thionin-stained cells were extremely sensitive to parasite exposure, as the density of cells in the skin of trout decreased markedly after exposure to the pathogens. Expand