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Transforming growth factor-β1 reduces apoptosis via autophagy activation in hepatic stellate cells
TLDR
The possible functions of TGF-β1-mediated autophagy in the pathological process of liver fibrosis are elucidated and rescued HSC-T6 cells from serum deprivation and reduce apoptosis viaAutophagy induction is elucidated.
Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells.
TLDR
Overexpressing of miR-148a increased autophagic activity, which inhibited proliferation and promoted apoptosis in HSCs, supporting a novel role for miR -148a as a key regulator of autophagy through the Hh signaling pathway.
Epigenetic modulation of insulin-like growth factor-II overexpression by hepatitis B virus X protein in hepatocellular carcinoma.
TLDR
It is suggested that CBP/p300-mediated acetylation of histones H3 and H4 may be a rate-limiting step for the hypomethylation and activation of these two promoters in HBx-mediated hepatocellular carcinoma.
The relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma.
TLDR
Investigation of the relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma (HCC) and to clarify the mechanism of HCC finds point mutation at codon 301 is one of the mechanisms of abnormal over-expression in HCC.
Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells
TLDR
Curcumin prevents carbon tetrachloride-induced liver fibrosis in rats and may be due to the inhibition of the activation of hepatic stellate cells and induction of their apoptosis.
Curcumin Promotes Apoptosis of Activated Hepatic Stellate Cells by Inhibiting Protein Expression of the MyD88 Pathway.
TLDR
It is demonstrated that curcumin promotes apoptosis of activated HSC by inhibiting the expression of cytokines related to the MyD88 pathway.
Curcumin, the main active constituent of turmeric (Curcuma longa L.), induces apoptosis in hepatic stellate cells by modulating the abundance of apoptosis-related growth factors
TLDR
Curcumin has an up-regulating effect on pro-apoptotic factors like Fas and p53 as well as a down- Regulating effect of the anti-ap optotic factor Bcl-2, thus inducing apoptosis in HSC.
Effect of curcumin on the proliferation and apoptosis of hepatic stellate cells.
TLDR
Curcumin inhibits the in vitro proliferation of HSCs in the G2/M phase of the cell cycle and also induces apoptosis in a concentration- and time-dependent manner.
[An improved method for the isolation of rat hepatic stellate cells].
TLDR
The method for the isolation of hepatic stellate cells was developed without Kupffer cells confusion, and the availability of highly purified stellates will facilitate the investigation of their functions in primary culture.
[Ultrastructural changes of duodenal mucosas and their significance in patients with liver cirrhosis].
TLDR
There were ultrastructural changes of duodenal mucosas in PLC, especially in end-stage PLC and these may have important pathophysiological and clinical significance.
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