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Redefined nomenclature for members of the carcinoembryonic antigen family.
- N. Beauchemin, P. Dráber, W. Zimmermann
- MedicineExperimental Cell Research
- 1 November 1999
Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.
- D. Pearson, J. Shively, H. Bern
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 August 1980
Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid…
Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts.
- S. Hu, L. Shively, A. Wu
- BiologyCancer Research
- 1 July 1996
Purified minibodies retained high affinity for CEA (KA, 2 x 10(9) M(-1)) and demonstrated bivalent binding to antigen and tumor targeting properties were evaluated in vivo using athymic mice bearing LS174T human colon carcinoma xenografts.
In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with 68Ga-Labeled DO3A-Exendin-4
- R. Selvaraju, I. Velikyan, O. Eriksson
- Biology, MedicineThe Journal of Nuclear Medicine
- 1 August 2013
The results strongly support the notion that 68Ga-DO3A-exendin-4 uptake in the pancreas is mediated by specific receptor binding and suggest that GLP-1R can be quantified in vivo, which has major implications for the prospect of imaging of native β-cells.
The Cell-Cell Adhesion Molecule Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Inhibits IL-2 Production and Proliferation in Human T Cells by Association with Src Homology Protein-1…
- Charng-jui Chen, J. Shively
- BiologyThe Journal of Immunology
- 15 March 2004
Carcinoembryonic Ag-related cellular adhesion molecule 1 associates with CD3 and is found in lipid rafts of PBMCs, is phosphorylated on the immunoreceptor tyrosine-based inhibitory motifs (ITIMs) of the -4L isoform, and associates with Src homology protein-1, providing an explanation for its inhibitory activity.
CEA-related antigens: molecular biology and clinical significance.
- J. Shively, J. Beatty
- BiologyCritical reviews in oncology/hematology
- 1985
CEACAM1-4S, a cell–cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture
- J. Kirshner, Charng-jui Chen, Pingfang Liu, Jie Huang, J. Shively
- BiologyProceedings of the National Academy of Sciences…
- 9 January 2003
A function of CEACAM1-4S relevant to cellular physiology that distinguishes it from its related long cytoplasmic domain isoform is revealed, suggesting that a morphogenic program integrates cell–cell and cell–extracellular matrix signaling to produce the lumena in mammary glands.
Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.
- V. Kenanova, T. Olafsen, A. Wu
- BiologyCancer research
- 15 January 2005
Antibody fragments are recognized as promising vehicles for delivery of imaging and therapeutic agents to tumor sites in vivo. The serum persistence of IgG1 and fragments with intact Fc region is…
CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex
- Rongze Lu, H. Pan, J. Shively
- BiologyPLoS pathogens
- 1 April 2012
It is found that LPS treated neutrophils induced phosphorylation of Syk resulting in the formation of a complex including TLR4, p-Syk, and p-CEACAM1, which in turn, recruited the inhibitory phosphatase SHP-1 which inhibits IL-1β production by the inflammasome.
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