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- Publications
- Influence
Redefined nomenclature for members of the carcinoembryonic antigen family.
- N. Beauchemin, P. Dráber, +22 authors W. Zimmermann
- Biology, Medicine
- Experimental cell research
- 1 November 1999
Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts.
- S. Hu, L. Shively, +5 authors A. Wu
- Chemistry, Medicine
- Cancer research
- 1 July 1996
A novel engineered antibody fragment (VL-VH-CH3, or "minibody") with bivalent binding to carcinoembryonic antigen (CEA) was produced by genetic fusion of a T84.66 (anti-CEA) single-chain antibody… Expand
The Cell-Cell Adhesion Molecule Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Inhibits IL-2 Production and Proliferation in Human T Cells by Association with Src Homology Protein-1…
- C. Chen, J. Shively
- Biology, Medicine
- The Journal of Immunology
- 15 March 2004
The cell adhesion molecule, carcinoembryonic Ag-related cellular adhesion molecule 1, shown by others to both activate and inhibit T cell proliferation, exhibits a reciprocal relationship to IL-2R… Expand
Development and Evaluation of 18F-TTCO-Cys40-Exendin-4: A PET Probe for Imaging Transplanted Islets
- Z. Wu, Shuanglong Liu, +9 authors F. Kandeel
- Chemistry, Medicine
- The Journal of Nuclear Medicine
- 1 February 2013
Because islet transplantation has become a promising treatment option for patients with type 1 diabetes, a noninvasive imaging method is greatly needed to monitor these islets over time. Here, we… Expand
In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with 68Ga-Labeled DO3A-Exendin-4
- R. Selvaraju, I. Velikyan, +6 authors O. Eriksson
- Chemistry, Medicine
- The Journal of Nuclear Medicine
- 1 August 2013
The glucagonlike peptide 1 receptor (GLP-1R) is mainly expressed on β-cells in the islets of Langerhans and is therefore an attractive target for imaging of the β-cell mass. In the present study,… Expand
124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice.
- G. Sundaresan, P. Yazaki, +7 authors A. Wu
- Chemistry, Medicine
- Journal of nuclear medicine : official…
- 1 December 2003
UNLABELLED
Prolonged clearance kinetics have hampered the development of intact antibodies as imaging agents, despite their ability to effectively deliver radionuclides to tumor targets in vivo.… Expand
Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.
- V. Kenanova, T. Olafsen, +12 authors A. Wu
- Chemistry, Medicine
- Cancer research
- 15 January 2005
Antibody fragments are recognized as promising vehicles for delivery of imaging and therapeutic agents to tumor sites in vivo. The serum persistence of IgG1 and fragments with intact Fc region is… Expand
Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments.
- P. Yazaki, A. Wu, +5 authors A. Raubitschek
- Chemistry, Medicine
- Bioconjugate chemistry
- 1 March 2001
Recombinant antibody fragments offer potential advantages over intact monoclonal antibodies in the radioimmunoscintigraphy (RIS) of solid tumors. Due to their smaller molecular size, antibody… Expand
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
- L. Chen, Zhangguo Chen, +19 authors R. Blumberg
- Biology, Medicine
- Immunity
- 16 November 2012
Carcinoembryonic antigen cell adhesion molecule like I (CEACAM1) is expressed on activated T cells and signals through either a long (L) cytoplasmic tail containing immune receptor tyrosine based… Expand
Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation.
- J. Esteban, Z. Warsi, M. Haniu, P. Hall, J. Shively, S. Chen
- Biology, Medicine
- The American journal of pathology
- 1 February 1992
The expression of aromatase was evaluated in 38 breast carcinomas by an immunohistochemical method (ABC) using an specific polyclonal antibody against human placental aromatase. Fifteen tumors (40%)… Expand
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