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Regulation of neurotrophin‐3 gene transcription by Sp3 and Sp4 in neurons
It is found that an NT‐3 transcript containing EIB is predominantly expressed in cortical neurons which preferentially utilize promoter B, and two tandemly repeated GC‐boxes are required for the transcription.
Developmental expression of the SRF co‐activator MAL in brain: role in regulating dendritic morphology
- J. Shiota, Mitsuru Ishikawa, H. Sakagami, M. Tsuda, J. Baraban, A. Tabuchi
- BiologyJournal of neurochemistry
- 1 September 2006
Findings indicate that the MAL‐SRF signaling pathway plays a key role in regulating dendritic morphology in adult brain and cultured cortical neurons.
Nuclear translocation of the SRF co‐activator MAL in cortical neurons: role of RhoA signalling
Findings demonstrate that RhoA signaling pathways are able to regulate transcription in neurons by triggering translocation of the SRF co‐activator MAL.
Involvement of the Serum Response Factor Coactivator Megakaryoblastic Leukemia (MKL) in the Activin-regulated Dendritic Complexity of Rat Cortical Neurons*
- Mitsuru Ishikawa, Naoki Nishijima, A. Tabuchi
- BiologyThe Journal of Biological Chemistry
- 13 August 2010
It is demonstrated that in addition to MKL1, MKL2, highly enriched in the forebrain, strongly contributes to the dendritic complexity, and this process is triggered by stimulation with activin, a member of the transforming growth factor β (TGF-β) superfamily.
Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1☆
Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons
The findings suggest that the subcellular localization of MKL1 isoforms, which is mediated by the number of actin-binding RPEL motifs, regulates their effect on SRF-mediated gene expression and dendritic morphology.
Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons.
Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells.
Isolation of actin-bound SRF coactivator MKL1 splice variants differentially expressed in the developing rat brain