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Cellular Contraction and Polarization Drive Collective Cellular Motion.
Coordinated motions of close-packed multicellular systems typically generate cooperative packs, swirls, and clusters. These cooperative motions are driven by active cellular forces, but the physical… Expand
Relating microstructure to rheology of a bundled and cross-linked F-actin network in vitro.
- J. Shin, M. Gardel, L. Mahadevan, P. Matsudaira, D. Weitz
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 29 June 2004
The organization of individual actin filaments into higher-order structures is controlled by actin-binding proteins (ABPs). Although the biological significance of the ABPs is well documented, little… Expand
Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes.
The immune system is closely linked to human metabolic diseases. Serum levels of IL-6 increase with obesity and insulin resistance. Not only does IL-6 decrease the insulin sensitivity of human cells… Expand
Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials.
Characterization of the properties of complex biomaterials using microrheological techniques has the promise of providing fundamental insights into their biomechanical functions; however, precise… Expand
Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
- I. Titushkin, S. Sun, J. Shin, M. Cho
- Biology, Medicine
- Journal of biomedicine & biotechnology
- 1 April 2010
Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment… Expand
Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo
Insulin secretion is elaborately modulated in pancreatic ß cells within islets of three-dimensional (3D) structures. Using human pluripotent stem cells (hPSCs) to develop islet-like structures with… Expand
Bending stiffness of a crystalline actin bundle.
- J. Shin, L. Mahadevan, P. T. So, P. Matsudaira
- Medicine, Biology
- Journal of molecular biology
- 19 March 2004
The acrosomal process of the sperm of the horseshoe crab (Limulus polyphemus) is a unique crystalline actin bundle, consisting of multiple actin filaments cross-linked by the actin-bundling protein,… Expand
Scaling of F-actin network rheology to probe single filament elasticity and dynamics.
- M. Gardel, J. Shin, F. MacKintosh, L. Mahadevan, P. Matsudaira, D. Weitz
- Physics, Medicine
- Physical review letters
- 29 October 2004
The linear and nonlinear viscoelastic response of networks of cross-linked and bundled cytoskeletal filaments demonstrates remarkable scaling with both frequency and applied prestress, which helps… Expand
Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation
- Kristina M. Giantsos-Adams, A. Koo, +5 authors C. Dewey
- Biology, Chemistry
- Cellular and molecular bioengineering
- 1 February 2013
The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone… Expand
The shallow turn of a worm
SUMMARY When crawling on a solid surface, the nematode Caenorhabditis elegans (C. elegans) moves forward by propagating sinusoidal dorso-ventral retrograde contraction waves. A uniform propagating… Expand