• Publications
  • Influence
The natural history of benign prostatic hyperplasia.
Strategies for asymptomatic microscopic hematuria: a prospective study of 1,034 patients.
Of the 246 patients with insignificant lesions and 563 with unexplained asymptomatic microscopic hematuria, no underlying lesion could be found and a diagnosis became clear within 3 years in 22 patients, including 3 cases of bladder carcinoma and 1 of prostatic carcinoma. Expand
Codon 877 Mutation in the Androgen Receptor Gene in Advanced Prostate Cancer: Relation to Antiandrogen Withdrawal Syndrome
The results indicate that a codon 877 mutation in the AR gene in advanced prostate cancer evokes the antiandrogen withdrawal syndrome and that the mutation is found in relation to endocrine therapy resistance. Expand
Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22‐p21.3
High‐resolution deletion mapping in 46 prostate cancers suggests that inactivation of tumor suppressor genes on 8p plays an important role in the progression of prostate cancer. Expand
A randomized trial comparing radical prostatectomy plus endocrine therapy versus external beam radiotherapy plus endocrine therapy for locally advanced prostate cancer: results at median follow-up of
For the treatment of patients with locally advanced prostate cancer, when combined with endocrine therapy, either radical prostatectomy or external beam radiotherapy demonstrated favorable long-term outcomes. Expand
Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers
The results suggest that inactivation of tumor suppressor genes on 16q plays an important role in the progression of prostate cancer. Expand
Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer.
The results have shown that patients with late urinary morbidity after carbon ion radiotherapy can be stratified according to the total number of risk genotypes they harbor. Expand
Carbon ion radiation therapy for prostate cancer: results of a prospective phase II study.
The effectiveness of C-ion RT for prostate cancer has been well confirmed and a new study of a C-ions RT modified for the administration strategy of ADT according to the patient risk has been started by dividing patients into 3 groups, high-risk, intermediate- risk, and low-risk. Expand
Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer
The results suggested that inactivation of one or more tumor suppressor genes on chromosome 10 plays an important role in late stages of prostate cancer. Expand
Progression of prostate cancer to neuroendocrine cell tumor
The clinical courses of four cases of neuroendocrine cell tumor that were found at autopsy are reported and it is shown that the progression to endocrine therapy‐resistant prostate cancer is partly due to clonal change to neuroendocrin cell tumor. Expand