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An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals
TLDR
An unexpected role for an OBP in taste is demonstrated and a molecular player involved in the integration of opposing attractive and aversive gustatory inputs is identified. Expand
Rab35 Mediates Transport of Cdc42 and Rac1 to the Plasma Membrane during Phagocytosis
TLDR
The data demonstrate that Rab35 is a regulator of vesicle transport required specifically for phagocytosis, and implicate Rab35 as the immune cell-specific regulator ofVsicle transport within the actin-remodeling complex. Expand
Down-Regulation of NF-κB Target Genes by the AP-1 and STAT Complex during the Innate Immune Response in Drosophila
TLDR
It is concluded that an inhibitory effect of AP-1 and STAT on NF-κB is required for properly balanced immune responses and appears to be evolutionarily conserved. Expand
Gustatory Receptors Required for Avoiding the Insecticide l-Canavanine
TLDR
It is shown that GRs are essential for responding to l-canavanine and that flies missing DmXR displayed normal l-Canavanine avoidance and l- canavanine-evoked action potentials, and that GR8a contributes to the specificity for l- Canavanine. Expand
Mechanosensory neurons control sweet sensing in Drosophila
TLDR
It is shown Drosophila prefers soft food at the expense of sweetness and that this preference requires labellar mechanosensory neurons (MNs) and the mechanosensing channel Nanchung, and this findings expand the understanding of the ways different sensory modalities cooperate to shape animal behaviour. Expand
The full repertoire of Drosophila gustatory receptors for detecting an aversive compound
TLDR
It is reported that three gustatory receptors, GR8a, GR66a and GR98b function together in the detection of L-canavanine, a plant-derived insecticide. Expand
dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia
TLDR
It is shown that the Drosophila Tubby homolog, King tubby (hereafter called dTULP) regulates ciliary localization of transient receptor potential (TRP) channels in cilia, and this suggests that dTulP is a protein that regulates cilia neurosensory functions. Expand
Identification and Functional Analysis of Antifungal Immune Response Genes in Drosophila
TLDR
This work identifies a new class of genes involved in antifungal immune responses in Drosophila that are involved specifically in defense against fungal infection. Expand
Modulation of Sweet Taste by Umami Compounds via Sweet Taste Receptor Subunit hT1R2
TLDR
The results suggest that umami peptides affect sweet taste receptors and this interaction prevents sweet receptor agonists from binding to the T1R2 ECD in an allosteric manner, not to theT1R3. Expand
Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa
TLDR
The results suggest that these compounds from the stem and leaves of A.rugosa are specific and selective agonists of hTRPA1. Expand
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