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Monoamine oxidase: from genes to behavior.
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.
Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.
Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.
The mouse cortico-striatal projectome
An open-access comprehensive mesoscale mouse cortico-striatal projectome is developed: a detailed connectivity projection map from the entire cerebral cortex to the dorsal striatum or caudoputamen in rodents, which identifies 29 distinct functional striatal domains.
A transient placental source of serotonin for the fetal forebrain
A new, direct role for placental metabolic pathways in modulating fetal brain development is revealed and indicates that maternal–placental–fetal interactions could underlie the pronounced impact of 5-HT on long-lasting mental health outcomes.
Monoamine oxidase inactivation: from pathophysiology to therapeutics.
Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.
The functions of MAO A and its repressor R1 in apoptotic signaling pathways are demonstrated and it is shown that R1 andMAO A act upstream of cyclin D1 and E2F1.
Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults
This study investigated the association between the self-reported serious and violent delinquency and the TaqI polymorphism in the DRD2 gene and the 40-bp VNTR in the DAT1 gene, finding no significant correlation between the two genetic variants.
The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity
A link between the rare 2 repeat of the 30-bp VNTR in the MAOA gene and much higher levels of self-reported serious and violent delinquency is demonstrated.
Human monoamine oxidase A and B genes exhibit identical exon-intron organization.
- J. Grimsby, K. Chen, L. J. Wang, N. Lan, J. Shih
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 May 1991
The results suggest that MAOA and MAOB are derived from duplication of a common ancestral gene and provide insight on the structural/functional relationship of the enzyme products.
Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis.
Findings suggest that MAOA has potential as a therapeutic target in PCa and functions to induce epithelial-to-mesenchymal transition (EMT) and stabilize the transcription factor HIF1α, which mediates hypoxia through an elevation of ROS, thus enhancing growth, invasiveness, and metastasis of PCa cells.