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Cytotoxic sterols from the formosan brown alga Turbinaria ornata.
Sterols 1, 2, and 4 exhibited cytotoxicity against various cancer cell lines and were converted into 29-hydroxystigmasta-5,24 (28)-dien-3beta-ol by reaction with LAH. Expand
Steroid and cembranoids from the Dongsha atoll soft coral Lobophytum sarcophytoides
A novel sterol, sarcophytosterol ( 1 ), and four new cembranoids, sarcophytolins A–D ( 2 – 5 ), have been isolated from the soft coral Lobophytum sarcophytoides along with four known metabolites 6 –Expand
Cytotoxic and anti-inflammatory cembranoids from the soft coral Lobophytum crassum.
Five new cembranoids, namely, crassumolides A and B and D-F (1 and 2 and 4-6), along with four known metabolites, 7-10, were isolated from the soft coral Lobophytum crASSum and the structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of the NMR data with those of known analogues. Expand
New β-Caryophyllene-Derived Terpenoids from the Soft Coral Sinularia nanolobata
The cytotoxicity of 1−6 against the growth of a limited panel of cancer cell lines is described and the structures of 1+5 were elucidated on the basis of extensive spectroscopic analyses and by comparison of the spectral data with those of the related metabolites. Expand
Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson’s model: a promising candidate for the treatment of Parkinson’s disease
It is concluded that 11-dehydrosinulariolide is a promising candidate for the treatment of Parkinson’s disease through its anti-apoptotic and anti-inflammatory action via PI3K signaling. Expand
Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin
The inhibitory effect of briarane-type diterpenes from marine coral Briareum excavatum on TPA-induced dermatitis and dendritic cell (DC) function was explored and suggest that BrDs warrant further investigation as natural immunomodulatory agents for control of inflammatory skin diseases. Expand
Five novel norcembranoids from Sinularia leptoclados and S. parva
Abstract Three new norcembrane-based diterpenoids, leptocladolides A ( 1 ), B ( 4 ) and C ( 5 ), along with five known metabolites 6 – 10 , have been isolated from the dichloromethane extract of aExpand
Oxygenated cembranoids from a Formosan soft coral Sinularia gibberosa.
Chemical investigation of a Formosan soft coral, Sinularia gibberosa, has led to the isolation of eight oxygenated cembranoids, including seven new compounds, gibberosenes A-G, which were found to be cytotoxic toward a limited panel of cancer cell lines. Expand
Suberosols A-D, four new sesquiterpenes with beta-caryophyllene skeletons from a Taiwanese gorgonian coral Subergorgia suberosa.
Four new beta-caryophyllene-derived sesquiterpenes alcohols, suberosols A (1), B (2), C (3), and D (4), along with two known beta-caryophyllene-derived sesqueterpene ketones, buddledins C (5) and DExpand
Structural Elucidation and Structure-Anti-inflammatory Activity Relationships of Cembranoids from Cultured Soft Corals Sinularia sandensis and Sinularia flexibilis.
Structural-activity relationship analysis indicated that cembrane-type compounds with one seven-membered lactone moiety at C-1 are potential anti-inflammatory agents. Expand