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Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
Amyloid beta peptide (Aβ) has a key role in the pathological process of Alzheimer's disease (AD), but the physiological function of Aβ and of the amyloid precursor protein (APP) is unknown. Recently,… Expand
Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
- Mansoureh Hakimi, T. Selvanantham, +14 authors Michael G. Schlossmacher
- Biology, Medicine
- Journal of Neural Transmission
- 7 May 2011
Sequence variants at or near the leucine-rich repeat kinase 2 (LRRK2) locus have been associated with susceptibility to three human conditions: Parkinson's disease (PD), Crohn’s disease and leprosy.… Expand
Circulating microRNAs levels in Chinese heart failure patients caused by dilated cardiomyopathy.
BACKGROUND Previous studies demonstrated dysregulated expression of microRNAs (miRNAs) in the myocardium of patients with dilated cardiomyopathy (DCM). This study investigated levels of miRNAs in the… Expand
Increased serum glycated albumin level is associated with the presence and severity of coronary artery disease in type 2 diabetic patients.
- Li Jin Pu, L. Lu, +10 authors S. Lou
- Circulation journal : official journal of the…
- 20 June 2007
BACKGROUND Glycated albumin is the predominant circulating Amadori-type glycated protein in vivo and plays a major role in the development of diabetic vascular complications. The aim of this study… Expand
Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes…
OBJECTIVES This study aimed to determine whether elevated serum levels of glycated albumin, high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor (TNF)-alpha were related to an… Expand
NeuroD1 A45T and PAX4 R121W polymorphisms are associated with plasma glucose level of repaglinide monotherapy in Chinese patients with type 2 diabetes.
- Z. Gong, Qiong Huang, +12 authors Z. Liu
- Biology, Medicine
- British journal of clinical pharmacology
- 1 September 2012
AIMS We aimed to determine whether NeuroD1/BETA2 and PAX4 polymorphisms were associated with the therapeutic efficacy of repaglinide in Chinese type 2 diabetes mellitus (T2DM) patients. METHODS… Expand
Clinical Reactivation of Herpes Simplex Virus Type 2 Infection in Seropositive Pregnant Women with No History of Genital Herpes
- L. Frenkel, E. Garratty, J. Shen, N. Wheeler, O. Clark, Y. Bryson
- Annals of Internal Medicine
- 15 March 1993
Abbreviations HSV = herpes simplex virus HSV-1 = herpes simplex virus type 1 HSV-2 = herpes simplex virus type 2 Seventy-eight to 97% of herpes simplex virus type 2 (HSV-2) infections are… Expand
miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro.
- J. Shen, R. Wan, +9 authors Xingpeng Wang
- Biology, Medicine
- Pancreatology : official journal of the…
- 1 March 2012
OBJECTIVES Activated pancreatic stellate cells (PSCs) play a pivotal role in the development of pancreatic diseases, especially chronic pancreatitis and pancreatic cancer. MicroRNAs have become a… Expand
Clinical benefits of adjunctive tirofiban therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
BackgroundThere is continued debate as to whether a combined reperfusion regimen with platelet glycoprotein IIb/IIIa inhibitor – tirofiban provides additional benefit in optimal myocardial… Expand
Interventions for emergency contraception.
- J. Shen, Y. Che, Emily Showell, K. Chen, L. Cheng
- The Cochrane database of systematic reviews
BACKGROUND Emergency contraception (EC) is using a drug or copper intrauterine device (Cu-IUD) to prevent pregnancy shortly after unprotected intercourse. Several interventions are available for EC.… Expand