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Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors.
TLDR
A variety of nongerm cell histologies, including sarcoma, adenocarcinoma, primitive neuroectodermal tumor and leukemia, may occur in association with germ cell tumor, and surgical resection is the mainstay of therapy.
Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression.
TLDR
The results suggest that T1 bladder cancers exhibiting nuclear overexpression of p53 protein have a higher probability of disease progression and suggests that p53 overeexpression is an important prognostic factor in these patients and may be useful in selecting appropriate therapy.
Phase I trial of intravesical gemcitabine in bacillus Calmette-Guérin-refractory transitional-cell carcinoma of the bladder.
TLDR
Gemcitabine has substantial activity as an intravesical agent in BCG-refractory TCC and warrants further investigation, which was associated with minimal bladder irritation and tolerable myelosuppression.
Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors.
TLDR
Four cycles of TIP as second-line therapy achieved a durable CR rate in a high proportion of patients with relapsed testicular GCT, emphasizing the importance of patient selection according to prognostic factors to achieve a favorable outcome to conventional-dose salvage therapy.
Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients.
TLDR
Dose-intense therapy with sequential, accelerated chemotherapy of paclitaxel/ifosfamide and carboplatin/etoposide administered with PBSC support was relatively well tolerated and the durable complete response proportion was substantial in patients with unfavorable prognostic features for achieving durable completeresponse to conventional-dose salvage programs.
Retroperitoneal lymph node dissection for nonseminomatous germ cell testicular cancer: impact of patient selection factors on outcome.
TLDR
For patients with normal STM and CS I to IIA disease, the low rate of systemic progression and 22% incidence of retroperitoneal teratoma supports RPLND as the preferred primary intervention.
Paclitaxel, ifosfamide, and cisplatin second-line therapy for patients with relapsed testicular germ cell cancer.
TLDR
Four cycles of TIP was associated with a high proportion of patients who achieved a complete response, a lack of relapse, and relative tolerability as an ifosfamide-containing salvage regimen for testicular GCTs, emphasizing the importance of patient selection according to prognostic factors for a favorable outcome to conventional-dose salvage therapy.
Association of the Lewis blood-group phenotype with recurrent urinary tract infections in women.
TLDR
There is an increased frequency of the Lewis blood-group nonsecretor (Le (a+b-] and recessive (Le(a-b-)] phenotypes among women with recurrent urinary tract infections.
NCCN clinical practice guidelines in oncology: kidney cancer.
Nonrandomized comparison of primary chemotherapy and retroperitoneal lymph node dissection for clinical stage IIA and IIB nonseminomatous germ cell testicular cancer.
PURPOSE Patients with clinical stage (CS) IIA and IIB nonseminomatous germ cell tumor (NSGCT) with adenopathy more than 2 cm, multiple masses, elevated serum tumor markers, or disease outside the
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