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Specific association of human telomerase activity with immortal cells and cancer.
Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In culturedExpand
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A survey of telomerase activity in human cancer.
Research on the association of the ribonucleoprotein enzyme, telomerase, with human cancer has expanded rapidly in recent years. Essentially all major types of cancer have been screened and theExpand
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Human Telomerase and Its Regulation
SUMMARY The telomere is a special functional complex at the end of linear eukaryotic chromosomes, consisting of tandem repeat DNA sequences and associated proteins. It is essential for maintainingExpand
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Telomerase activity in human germline and embryonic tissues and cells.
Telomerase is a ribonucleoprotein that synthesizes telomere repeats onto chromosome ends and is involved in maintaining telomere length in germline tissues and in immortal and cancer cells. In theExpand
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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
The hallmarks of telomere dysfunction in mammals are reduced telomeric 3′ overhangs, telomere fusions, and cell cycle arrest due to a DNA damage response. Here, we report on the phenotypes ofExpand
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Adult-onset pulmonary fibrosis caused by mutations in telomerase
Idiopathic pulmonary fibrosis (IPF) is an adult-onset, lethal, scarring lung disease of unknown etiology. Some individuals with IPF have a familial disorder that segregates as a dominant trait withExpand
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Telomere Position Effect in Human Cells
In yeast, telomere position effect (TPE) results in the reversible silencing of genes near telomeres. Here we demonstrate the presence of TPE in human cells. HeLa clones containing a luciferaseExpand
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Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells.
Telomerase is a reverse transcriptase that adds telomeric repeats to chromosomal ends. In most normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading toExpand
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Normal human chromosomes have long G-rich telomeric overhangs at one end.
Telomeres protect the ends of linear chromosomes from degradation and abnormal recombination events, and in vertebrates may be important in cellular senescence and cancer. However, very little isExpand
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Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)
The association of human telomerase activity with an indefinite replicative capacity of cells in vitro and advanced tumors in vivo is gaining wide support. The increasing interest in studying variousExpand
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