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A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases.
It is suggested that nonperfusion of apparently normal lung acini is a major factor in late-phase deaths in those mouse strains which show little or no fibrosis. Expand
Development of fibrosis after lung irradiation in relation to inflammation and lung function in a mouse strain prone to fibrosis.
The development of lung fibrosis after single-dose thoracic irradiation was studied histologically in C57L/J male mice and the average number of macrophages per unit area of fibrosis declined during the latent period and changed little during the early and late phases. Expand
Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and "non-fibrosing" mice during the latent period and early phase…
The association of active TGF-beta with fibroblasts might be a characteristic of the initiation of fibrosis in this model. Expand
A marker for hypoxic cells in tumours with potential clinical applicability.
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Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.
- A. Franko, C. Koch, B. Garrecht, J. Sharplin, D. Hughes
- Chemistry, Medicine
- Cancer research
- 15 October 1987
The properties of misonidazole binding indicate that it should be a good marker for radiobiological hypoxia in tumors, providing adequate controls can be performed. Expand
A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase.
The degree of lung impairment in mice dying of respiratory insufficiency was assessed by scoring lung acini as nonfunctional or open and presumably functional, and over 70% of acini were nonfunctional as a result of airflow obstruction. Expand
The genetic basis of strain-dependent differences in the early phase of radiation injury in mouse lung.
The phenotype in which fibrosis is found is controlled by autosomal recessive determinants, and strains prone to radiation-induced pulmonary fibrosis and hyaline membranes exhibited intrinsically lower activities of lung plasminogen activator and angiotensin converting enzyme than either the nonfibrosing strains or the nonmagnifying hybrid crosses. Expand
Evidence for two patterns of inheritance of sensitivity to induction of lung fibrosis in mice by radiation, one of which involves two genes.
It is suggested that two autosomal genes which function additively determine the extent of the principal type of fibrosis in these strains and in the F1 mice this unusual fibrosis appears to be regulated independently by two additional genes, one of which is sex-linked. Expand
Critical volume model analysis of lung complication data from different strains of mice
- P. Stavrev, N. Stavreva, J. Sharplin, B. Fallone, A. Franko
- Biology, Medicine
- International journal of radiation biology
- 1 January 2005
The critical volume (CV) normal tissue complication probability (NTCP) model was used to fit experimental data on radiation pneumonitis in mice to test the model and determine the values of the model… Expand
Wing Base Structure in Lepidoptera II. Hind Wing Base
- J. Sharplin
- 1 October 1963
The fore wing bases of Monotrysia can be homologized with the plan for a generalized insect wing base (Snodgrass, 1935) and the jugum is particularly interesting; it is present in all the members of the old group “Microlepidoptera” and not only in the Monotsia or “Jugatae”. Expand