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- Publications
- Influence
Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse.
- J. Sharma, J. Turk, J. McHowat
- Biology, Medicine
- Biochemistry
- 6 July 2010
Damage and activation of lung endothelium can lead to interstitial edema, infiltration of inflammatory cells into the interstitium and airways, and production of inflammatory metabolites, all of… Expand
Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung.
- J. McHowat, G. Gullickson, R. G. Hoover, J. Sharma, J. Turk, J. Kornbluth
- Medicine
- American journal of physiology. Cell physiology
- 1 April 2011
We determined the contribution of calcium-independent phospholipase A(2)β (iPLA(2)β) to lung metastasis development following breast cancer injection into wild-type (WT) and iPLA(2)β-knockout… Expand
The Absence of Myocardial Calcium-Independent Phospholipase A2γ Results in Impaired Prostaglandin E2 Production and Decreased Survival in Mice with Acute Trypanosoma cruzi Infection
- J. Sharma, C. Eickhoff, D. Hoft, David A. Ford, R. Gross, J. McHowat
- Biology, Medicine
- Infection and Immunity
- 19 February 2013
ABSTRACT Cardiomyopathy is a serious complication of Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi. The parasite often infects cardiac myocytes, causing the release of… Expand
Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure.
- J. Sharma, Dawn M Young, John O. Marentette, P. Rastogi, J. Turk, J. McHowat
- Biology, Medicine
- American journal of physiology. Lung cellular and…
- 2012
An early event in the pathogenesis of emphysema is the development of inflammation associated with accumulation of polymorphonuclear leukocytes (PMN) in small airways, and inflammatory cell… Expand
Absence of calcium‐independent phospholipase A2β impairs platelet‐activating factor production and inflammatory cell recruitment in Trypanosoma cruzi‐infected endothelial cells
- J. Sharma, C. Eickhoff, D. Hoft, John O. Marentette, J. Turk, J. McHowat
- Biology, Medicine
- Physiological reports
- 1 January 2014
Both acute and chronic phases of Trypanosoma cruzi (T. cruzi) infection are characterized by tissue inflammation, mainly in the heart. A key step in the inflammatory process is the transmigration of… Expand
PGE2 Release from Tryptase-Stimulated Rabbit Ventricular Myocytes is Mediated by Calcium-Independent Phospholipase A2γ
- J. Sharma, J. McHowat
- Biology, Medicine
- Lipids
- 2 April 2011
Inflammation is associated with cardiovascular disease, including myocardial infarction, atherosclerosis, myocarditis and congestive heart failure. Mast cells have been implicated in inflammation,… Expand
Mice with Genetic Deletion of Group VIA Phospholipase A2β Exhibit Impaired Macrophage Function and Increased Parasite Load in Trypanosoma cruzi-Induced Myocarditis
- J. Sharma, Jennifer R. Blase, D. Hoft, John O. Marentette, J. Turk, J. McHowat
- Biology, Medicine
- Infection and Immunity
- 8 February 2016
ABSTRACT Trypanosoma cruzi infection, which is the etiological agent of Chagas disease, is associated with intense inflammation during the acute and chronic phases. The pathological progression of… Expand
Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles
- M. Yamoah, Maryam Moshref, +9 authors X. Zhang
- Chemistry, Medicine
- International journal of nanomedicine
- 5 October 2018
Purpose The delivery of transgenes into human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSC-CMs) represents an important tool in cardiac regeneration with potential for clinical… Expand
Activation of group VI phospholipase A2 isoforms in cardiac endothelial cells.
- J. Sharma, J. Turk, D. Mancuso, H. Sims, R. Gross, J. McHowat
- Biology, Medicine
- American journal of physiology. Cell physiology
- 1 April 2011
The endothelium comprises a cellular barrier between the circulation and tissues. We have previously shown that activation of protease-activated receptor 1 (PAR-1) and PAR-2 on the surface of human… Expand
Polymorphonuclear leukocytes isolated from umbilical cord blood as a useful research tool to study adherence to cell monolayers.
- J. Sharma, P. Rastogi, M. Creer, J. McHowat
- Medicine
- Journal of immunological methods
- 31 December 2009
One of the initial steps in the inflammatory process involves the adherence and transmigration of circulating polymorphonuclear leukocytes (PMN) across the endothelial cell monolayer. One of the main… Expand