Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.
- S. Kersten, J. Seydoux, J. Peters, F. Gonzalez, B. Desvergne, W. Wahli
- BiologyJournal of Clinical Investigation
It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR alpha mRNA is induced during fasting in wild-type mice, indicating that PPARalpha plays a pivotal role in the management of energy stores during fasting.
Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
These animal models demonstrate that AGT produced by adipose tissue plays a role in both local adipOSE tissue development and in the endocrine system, which supports a role of adipose AGT in hypertensive obese patients.
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR α mRNA is induced during fasting in wildtype mice, indicating that PPARα plays a pivotal role in the management of energy stores during fasting.
Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity
- A. Dulloo, J. Seydoux, L. Girardier, P. Chantre, J. Vandermander
- Chemistry, MedicineInternational Journal of Obesity
- 1 February 2000
It is proposed that the green tea extract is effective in stimulating thermogenesis by relieving inhibition at different control points along the NA–cAMP axis, and a synergistic interaction between catechin-polyphenols and caffeine to augment and prolong sympathetic stimulation of thermogenesis could be of value in assisting the management of obesity.
Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
The issue of the high content of linoleic acid of ingested lipids during pregnancy and lactation, and formula milk and infant foods in relation to the epidemic of childhood obesity is raised.
Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
The results demonstrate the importance of NPY Y1 receptors in NPY-mediated cardiovascular response and in the regulation of body weight through central control of energy expenditure and are also indicative of a role for the Y1 receptor in the control of food intake.
Angiotensinogen-Deficient Mice Exhibit Impairment of Diet-Induced Weight Gain with Alteration in Adipose Tissue Development and Increased Locomotor Activity.
Comparative studies showed that agt−/− mice gain less weight than wild-type mice in response to a chow or high fat diet, and cellularity measurement indicated hypotrophy of adipocytes in AGT-deficient mice with a parallel decrease in the fatty acid synthase activity.
Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?
These tissue‐dependent differential mRNA expressions of the UCP homologues in IBAT, gastrocnemius, and soleus muscles during food deprivation and refeeding are much more consistent with a role for UCP2 and UCP3 in the regulation of lipids as fuel substrate rather than as mediators of regulatory thermogenesis.
In vivo activation of PPAR target genes by RXR homodimers
Using in vivo chromatin immunoprecipitation, it is shown that RXR homodimers can selectively bind to functional PPREs and induce transactivation, which can rescue the severe hypothermia phenotype observed in fasted PPARα−/− mice.