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Publications Influence

Statistical mechanical approaches to models with many poorly known parameters.

- K. S. Brown, J. Sethna
- Mathematics, Medicine
- Physical review. E, Statistical, nonlinear, and…
- 12 August 2003

Models of biochemical regulation in prokaryotes and eukaryotes, typically consisting of a set of first-order nonlinear ordinary differential equations, have become increasingly popular of late. These… Expand

355 26- PDF

Crackling noise

Crackling noise arises when a system responds to changing external conditions through discrete, impulsive events spanning a broad range of sizes. A wide variety of physical systems exhibiting… Expand

625 18- PDF

Abrupt buckling transition observed during the plectoneme formation of individual DNA molecules.

- Scott Forth, C. Deufel, M. Y. Sheinin, B. Daniels, J. Sethna, M. Wang
- Materials Science, Medicine
- Physical review letters
- 11 April 2008

The response of single DNA molecules to externally applied forces and torques was directly measured using an angular optical trap. Upon overwinding, DNA buckled abruptly as revealed by a sharp… Expand

164 15- PDF

Parameter Space Compression Underlies Emergent Theories and Predictive Models

- Benjamin B. Machta, Ricky Chachra, M. Transtrum, J. Sethna
- Physics, Mathematics
- Science
- 27 March 2013

Information Physics Multiparameter models, which can emerge in biology and other disciplines, are often sensitive to only a small number of parameters and robust to changes in the rest; approaches… Expand

186 15- PDF

Intra-unit-cell electronic nematicity of the high-Tc copper-oxide pseudogap states

In the high-transition-temperature (high-Tc) superconductors the pseudogap phase becomes predominant when the density of doped holes is reduced. Within this phase it has been unclear which electronic… Expand

333 13- PDF

Coulomb blockade and the Kondo effect in single-atom transistors

- J. Park, A. Pasupathy, +8 authors D. Ralph
- Physics, Medicine
- Nature
- 13 June 2002

Using molecules as electronic components is a powerful new direction in the science and technology of nanometre-scale systems. Experiments to date have examined a multitude of molecules conducting in… Expand

1,452 10- PDF

Theory of the blue phase of cholesteric liquid crystals.

- S. Meiboom, J. Sethna, P. Anderson, P. Anderson, W. Brinkman
- Materials Science
- 1981

275 10

Geometry of nonlinear least squares with applications to sloppy models and optimization.

- M. Transtrum, Benjamin B. Machta, J. Sethna
- Mathematics, Physics
- Physical review. E, Statistical, nonlinear, and…
- 7 October 2010

Parameter estimation by nonlinear least-squares minimization is a common problem that has an elegant geometric interpretation: the possible parameter values of a model induce a manifold within the… Expand

115 7- PDF

Universal properties of the transition from quasi-periodicity to chaos

- S. Ostlund, D. Rand, E. Siggia, J. Sethna
- Mathematics, Computer Science
- 1 September 1983

TLDR

219 7- PDF

Sloppy-model universality class and the Vandermonde matrix.

- J. J. Waterfall, Fergal P. Casey, +5 authors J. Sethna
- Mathematics, Physics
- Physical review letters
- 15 May 2006

In a variety of contexts, physicists study complex, nonlinear models with many unknown or tunable parameters to explain experimental data. We explain why such systems so often are sloppy: the system… Expand

132 6- PDF