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Structure of apolipoprotein B-100 in low density lipoproteins.
TLDR
The existing experimental and computational evidence for the pentapartite domain structure of apoB is examined, showing the likelihood that the betaalpha(1) domain is a globular composite of alpha-helical and beta-sheet secondary structures that participates in lipid accumulation in the co-translationally assembled prenascent triglyceride-rich lipoprotein particles. Expand
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells.
TLDR
The properties, distribution, localization, and potential functions of perilipins and ADRP, as well as those of vimentin and the recently-described 'capsular' proteins, in lipid storage and metabolism are discussed. Expand
The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.
TLDR
It is of particular interest, therefore, that all of the exchangeable apolipoproteins except apoA-II and C-I, contain amphipathic helixes of class G*. Expand
A Detailed Molecular Belt Model for Apolipoprotein A-I in Discoidal High Density Lipoprotein*
TLDR
Apolipoprotein A-I is the principal protein of high density lipoprotein particles (HDL), and this work proposes a detailed model for the smallest discoidal HDL, consisting of two apoA-I molecules wrapped beltwise around a small patch of bilayer containing 160 lipid molecules. Expand
Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor.
TLDR
A rapid method has been developed for separation of the major plasma lipoproteins from up to 96 ml of plasma by a single ultracentrifugation step and cholesterol levels in HDL fractions separated by this method have significantly lower values than those estimated by the heparin-manganese chloride precipitation method. Expand
The amphipathic alpha helix: a multifunctional structural motif in plasma apolipoproteins.
TLDR
This chapter reviews the different classes of amphipathic helices in apolipoproteins, using a combination of powerful computer programs to develop a comparison database and to analyze these structures. Expand
Increased prevalence of smaller and denser LDL particles in Asian Indians.
TLDR
It is concluded that the increased prevalence of small, dense LDL observed in Asian Indians might contribute to their increased CHD risk. Expand
Science and Society.
TLDR
If the elaboration of scientific methods of production and management is increasing, even if temporarily, the volume of unemployment, it is at least intelligible that labour should be dubious about acknowledging or accepting that leadership of science. Expand
Membrane interactions of synthetic peptides corresponding to amphipathic helical segments of the human immunodeficiency virus type-1 envelope glycoprotein.
TLDR
It is suggested that the amphipathic helical segments near the carboxyl terminus of HIV envelope proteins may play a role in lysis of HIV-infected cells and also may modulate the extent of cell fusion observed during HIV infection of CD4+ cells. Expand
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