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Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats.
TLDR
BPA should not be considered a selective reproductive toxicant, based on the results of this study, and no evidence of nonmonotonic dose-response curves across generations for either sex is found.
Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice.
TLDR
Dietary bisphenol A was evaluated in a mouse two-generation study and there were no treatment-related effects and no evidence of nonmonotonic dose-response curves for any parameter, therefore, BPA is not considered a selective reproductive or developmental toxicant in mice.
Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System
TLDR
A widely accepted and utilized international harmonization of nomenclature for urinary tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
Phenolphthalein Induces Thymic Lymphomas Accompanied by Loss of the p53 Wild Type Allele in Heterozygous p53-Deficient (±) Mice
TLDR
Exposure to phenolphthalein combined with a genetic predisposition to cancer can potentiate the carcinogenic process and cause p53 gene alterations, a gene alteration found in many human cancers.
The Effect of Chronic Progressive Nephropathy on the Incidence of Renal Tubule Cell Neoplasms in Control Male F344 Rats
TLDR
A marginal association suggests that the number of RTCNs that may develop secondary to chemically exacerbated nephropathy would be few, and there is a positive correlation between CPN and RTCN, although cause and effect were not determined.
Two-generation reproductive toxicity evaluation of dietary 17beta-estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) mice.
TLDR
The mouse model is sensitive to E2 by oral administration, with effects on reproductive development at doses of 10- 100 mug/kg/day, and on F0/F1 estrous cyclicity, F0-F1 andrology, or F1/F2 anogenital distance at any dose.
Two-generation reproduction study with para-tert-octylphenol in rats.
TLDR
This study supports the increasing evidence that screening assays for estrogenic activity or studies with limited numbers of animals and/or unrealistic dose regimens are inappropriate for use in the assessment of human health and environmental risk.
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