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Simultaneous In Vivo Visualization and Localization of Solid Oral Dosage Forms in the Rat Gastrointestinal Tract by Magnetic Resonance Imaging (MRI)
AbstractPurpose. Bioavailability of orally administered drugs is much influenced by the behavior, performance and fate of the dosage form within the gastrointestinal (GI) tract. Therefore, MRI in… Expand
Acute effects of tumor necrosis factor alpha or lymphotoxin on global blood flow, laser Doppler flux, and bioenergetic status of subcutaneous rodent tumors.
Global blood flow (TBF), tumor vascular resistance, laser Doppler flow in superficial tumor areas, and mean arterial blood pressure were evaluated in rats bearing s.c. DS sarcomas. Measurements were… Expand
Diffusion- and T2-weighted imaging: evaluation of oedema reduction in focal cerebral ischaemia by the calcium and serotonin antagonist levemopamil.
Magnetic resonance imaging (MRI) was used to evaluate beneficial drug effects in a rat model of focal cerebral ischaemia. Extent of cerebral oedema was measured on T2-weighted images 24 hr after… Expand
Oedema reduction by levemopamil in focal cerebral ischaemia of spontaneously hypertensive rats studied by magnetic resonance imaging.
The effect of treatment with the Ca2+ channel blocker and 5-HT2 receptor antagonist levemopamil (recommended INN for (S)-emopamil) on the extent of ischaemic brain oedema was studied by magnetic… Expand
Magnetic Resonance Imaging Study on the Effect of Levemopamil on the Size of Intracerebral Hemorrhage in Rats
Beneficial effects of calcium antagonists in cerebral ischemia and trauma have been attributed in part to improved cerebral blood flow. Enhancement of cerebral blood flow, however, could aggravate… Expand
MRI study on delayed ancrod therapy of focal cerebral ischaemia in rats.
The therapeutic window for efficient post-treatment of focal cerebral ischaemia with the fibrinogen lowering agent ancrod was studied by magnetic resonance imaging (MRI) in spontaneously hypertensive… Expand
Diffusion-weighted MRI and perfusion echo-planar imaging in a rat stroke model
Two new MR techniques, diffusion-weighted imaging and perfusion imaging, are capable of displaying ischaemic areas within minutes after the onset of ischaemia. Ischaemia was induced in eight rats… Expand
SYNTHESIS AND PROPERTIES OF COMPOUNDS RELATED TO 1-t-BUTYLACETYLENE-2-PHOSPHONIC ACID AND 1-t-BUTYLETHANE-1,2,2-TRIPHOSPHONIC ACID. STERICALLY OVERCROWDED PHOSPHORUS COMPOUNDS, PART I:
Abstract I-t-Butylacetylene-2-phosphonic acid diethyl and di-iso-propyl esters, 6a, 6b were synthesized via the NiCl2 promoted MICHAELIS-ARBUZOV-type reactions. Ethyl, iso-propyl and methyl esters… Expand
MENTHYL-SUBSTITUTED ORGANO-PHOSPHORUS-COMPOUNDS. VII1: FLUORINATED COMPOUNDS AND DERIVATIVES
Abstract The synthesis of a series of compounds, containing the (–)-menthyl group, bonded to tri-, tetra- and penta-coordinate phosphorus is described. Specifically, the formation of… Expand
Novel One-Pot Syntheses for Oligo-Phosphonic and Phosphinic Acid Esters.