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Similar frequency of rhinovirus-infectible cells in upper and lower airway epithelium.
TLDR
It is suggested that lower airway dysfunction occurs through this mechanism in susceptible persons through the infectivity of RV serotype 16 in primary bronchial and adenoidal epithelial cells.
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Comparison of airway and blood eosinophil function after in vivo antigen challenge.
TLDR
It is indicated that BAL EOS have an enhanced [Ca2+]i response to activation that may contribute to their functional up-regulation, and blood and airway EOS responded similarly to PMA.
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IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction.
TLDR
The findings suggest that the eosinophil survival activity in the late inflammatory lesions following SBP with allergen is mainly associated with IL-5, with small contributions from GM-CSF.
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Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after…
TLDR
Observations provide a potential explanation for the inability of anti-IL-5 therapy to suppress airway hyperresponsiveness to inhaled Ag, despite a reduction in eosinophil recruitment.
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Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators.
TLDR
It is suggested that eosinophils are attracted to the airway during the late-phase allergic reaction and that IL-5 may produce changes in airway eos inophil density and promote the release of granular proteins to cause airway injury.
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The effect of platelet-activating factor on the generation of superoxide anion in human eosinophils and neutrophils.
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Differential regulation of eosinophil adhesion and transmigration by pulmonary microvascular endothelial cells.
TLDR
The results suggest that EOS adhesion and transmigration are differentially regulated by VCAM-1 and ICam-1 expression and the interaction of these adhesion proteins with their respective counterligands, i.e., alpha4 and beta2 integrins on EOS.
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Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration.
TLDR
Select cytokines, generated in response to RV infection, can increase vascular permeability and might provide a mechanism by which RV infection can lead to edema, cellular infiltration, and inflammation and thus compromised airflow.
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Respiratory syncytial virus infection enhances neutrophil and eosinophil adhesion to cultured respiratory epithelial cells. Roles of CD18 and intercellular adhesion molecule-1.
TLDR
RSV infections of respiratory epithelial monolayers can promote inflammatory cell adherence which could, in turn, potentially contribute to the airway injury and obstruction that accompanies bronchiolitis.
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Superoxide generation by hypodense eosinophils from patients with asthma.
TLDR
Blood HE in asthma do not necessarily have enhanced function, and eosinophil heterogeneity extends not only to cell density but is also reflected in cell function and that these cell variations are dependent on many factors, including the function assessed, source of cells, and stimulus used.
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