J. Scrivens

Publications137
h-index39
Citations4,957
Highly Influential Citations102
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An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument
Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase
TLDR
The identification and characterization of trimethylamine (TMA) monooxygenase, termed Tmm, from Methylocella silvestris, and the ability of MRC to use TMA as a sole carbon and/or nitrogen source is directly linked to the presence of tmm in the genomes.
A comparison of labeling and label-free mass spectrometry-based proteomics approaches.
TLDR
The proteome of the recently discovered bacterium Methylocella silvestris has been characterized using three profiling and comparative proteomics approaches and results obtained have been compared with respect to number of proteins identified, confidence in identification, sequence coverage and agreement of regulated proteins.
Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements.
TLDR
The results illustrate that the TWIMS approach can provide data on three-dimensional protein structures of biological relevance, and the relative stability of gas-phase structures has been investigated, based on their change in cross-section with increase in charge.
Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways
TLDR
The first identification of both GnRH-type and CRZ-type signalling systems in a deuterostome–the echinoderm (starfish) Asterias rubens is identified and it is demonstrated that the vertebrate/deuterostomian GnRH/AKH systems are orthologous and the origin of a paralogous CR z type signalling system can be traced to the common ancestor of the Bilateria.
The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin.
TLDR
Three ionisation techniques that require no sample preparation or extraction prior to mass analysis for the rapid analysis of pharmaceutical tablets and ointments are used and accurate DESI and DAPCI tandem mass spectra were obtained and these greatly enhance the selectivity and information content of the experiment.
Estimating collision cross sections of negatively charged N-glycans using traveling wave ion mobility-mass spectrometry.
TLDR
A calibration data set consisting of over 500 reference CCSs for negatively charged N-glycans and their fragments is presented and it is shown that dextran, already widely used as a calibrant in high performance liquid chromatography, is also a suitable calibrant for CCS estimations.
Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs.
TLDR
The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data and showed good agreement with publishedData.
Probing hemoglobin structure by means of traveling-wave ion mobility mass spectrometry
A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis
TLDR
The results presented here compose the most comprehensive coverage of the exoproteome of a corynebacterial species so far, and evidence could be found for probable non-classical export of most of the remaining proteins.
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