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State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.
TLDR
The state of HBV DNA in the liver of 13 patients with hepatocellular carcinoma, 17 patients with chronic hepatitis, and 2 patients with acute hepatitis was studied and discrete bands were observed, suggesting the existence of limited and specific integration sites in host cellular DNA. Expand
Presence of HBV DNA in spermatozoa: A possible vertical transmission of HBV via the germ line
TLDR
It is indicated that HBV DNA may be present in the semen, at least during the acute phase of HBV infection, and the presence of integrated sequences in spermatozoa suggests the possibility of true vertical transmission ofHBV via the germ line. Expand
Severe giant cell hepatitis with autoimmune hemolytic anemia in early childhood.
TLDR
Four children, aged 6 1/2 months to 2 years, presented with liver disease and autoimmune hemolytic anemia, resulting in the death of three patients from liver failure, which seemed responsive to corticosteroid treatment, which in one patient was clearly beneficial. Expand
Neonatal adrenoleukodystrophy.
TLDR
Clinical, histopathological and biochemical findings of these nine cases are compared to those reported in other neonatal adrenoleukodystrophy cases and to those of other Neonatal peroxisomal disorders, that is cerebro-hepato-renal syndrome of Zellweger and infantile Refsum's disease. Expand
A new peroxisomal disorder with enlarged peroxisomes and a specific deficiency of acyl-CoA oxidase (pseudo-neonatal adrenoleukodystrophy).
TLDR
The clinical, biochemical, and cytochemical features found in these two siblings are compared with those seen in two other disorders characterized by the absence of a decreased number of hepatic peroxisomes and the presence of VLCFA. Expand
Detection of Hepatitis B Virus DNA in Serum by a Simple Spot Hybridization Technique: Comparison with Results for Other Viral Markers
TLDR
A simplified spot method for determination in serum of hepatitis B virus DNA (HBV DNA) by molecular hybridization is proposed, which greatly reduced the duration of the steps preceding hybridization proper and allowed more sensitive detection in samples of only 25 or 50 m̈1. Expand
Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome
TLDR
The results show that the different steps of HBV multiplication can take place in nonliver nonhuman cells once the problem of entry into the host cell is overcome. Expand
DETECTION OF HEPATITIS B VIRUS DNA IN LIVER AND SERUM: A DIRECT APPRAISAL OF THE CHRONIC CARRIER STATE
TLDR
The hybridisation technique appears to be a very sensitive test which could reflect viral multiplication better than HBeAg radioimmunoassay and should be useful in understanding chronic hepatitis, the selection of patients for antiviral therapy, and the estimation of its efficiency. Expand
Pathological study of alpha‐chain disease, with special emphasis on evolution
TLDR
The pathology of six cases of alpha‐chain disease (α‐CD), four of which were followed until complete remission or death, was studied by histologic, immunofluorescence and ultrastructural techniques and will determine the precise frequency of α‐CD protein synthesis in the latter syndrome. Expand
Hepatic peroxisomes are deficient in infantile refsum disease: a cytochemical study of 4 cases.
TLDR
Peroxisomes and birefringent macrophages were absent in 2 patients with the cerebrohepatorenal syndrome of Zellweger; the simultaneous presence of these unique light microscopical characteristics may be of diagnostic value. Expand
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