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Porcine endogenous retroviruses: in vitro host range and attempts to establish small animal models.
Using transgenic pigs as the source of cells or organs for xenotransplantation is associated with the risk of porcine endogenous retrovirus (PERV) transmission. Multiple proviruses are integratedExpand
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Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues.
Defects in the autoimmune regulator (AIRE) gene cause the monogenic autoimmune disease autoimmune polyendocrinopathy syndrome type 1 (APS-1), which is characterized by a loss of self-tolerance toExpand
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Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors.
Bone marrow of breast cancer patients was found to contain CD8(+) T cells specific for peptides derived from breast cancer-associated proteins MUC1 and Her-2/neu. Most of these cells had a central orExpand
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Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity.
Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing organ-specific autoimmunity. This apparent paradox is in part explained by promiscuous expression ofExpand
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Maintenance of long‐term tumour‐specific T‐cell memory by residual dormant tumour cells
LacZ (Gal)‐reactive immune cells were transferred into athymic nu/nu mice inoculated with Gal‐expressing syngeneic tumour cells (ESbL‐Gal) in order to study tumour‐protective T‐cell memory. ThisExpand
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Dynamic Differentiation of Activated Human Peripheral Blood CD8+ and CD4+ Effector Memory T Cells
Two functionally different memory T cell subsets were originally defined based on their different CCR7 expression profile, but the lineage relationship between these subsets referred to as centralExpand
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Porcine endogenous retroviruses (PERVs): generation of specific antibodies, development of an immunoperoxidase assay (IPA) and inhibition by AZT.
Xenotransplantation may be associated with the risk of transmission of microorganisms. In particular, the porcine endogenous retroviruses (PERV) have raised concerns as in vitro experiments showExpand
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Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors
: Bone marrow of breast cancer patients was found to contain CD8(+) T cells specific for peptides derived from breast cancer-associated proteins MUC1 and Her-2/neu. Most of these cells had a centralExpand
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