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The Catalog of Human Hair Keratins
TLDR
In situ hybridization and immunohistochemical expression studies on scalp follicles show that two hair keratins define the early stage of hair differentiation, i.e. hHa5 expression in hair matrix and hHa4/hHa2 coexpression in the early hair cuticle cells.
A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.
TLDR
It is shown that the new cytokeratin K6hf is exclusively expressed in the so-called "companion layer" of the hair follicle, a single layered band of flat and vertically oriented cells between the cuboidal ORS cells and the IRS that stretches from the lowermost bulb region to the isthmus of the follicle.
A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath.
TLDR
A cDNA clone encoding a cytokeratin family member was isolated and the predicted amino acid sequence derived from this clone revealed a homology with a number of cytokeratins, not only in the central alpha-helical regions but also in the conserved portions of the amino and carboxy terminal domains, indicating that this protein represents a new member of the mouse type II cytokersatin family.
Aberrant expression during two‐stage mouse skin carcinogenesis of a type 147‐kDa keratin, k13, normally associated with terminal differentiation of internal stratified epithelia
TLDR
The results suggest that K13 may provide a marker for malignant conversion in the mouse two‐stage skin carcinogenesis model and may be especially suited for studies of gene expression regulation.
Sequence and expression of murine type I hair keratins mHa2 and mHa3.
TLDR
A cDNA library constructed with poly(A)+ RNA from mouse tail epidermis which contained all hair follicles of tail skin revealed a structural heterogeneity within the type I hair keratin subfamily that is functionally relevant in the morphogenesis of hard alpha-keratin-expressing tissues.
The Catalog of Human Hair Keratins
TLDR
Comparing analysis of type II with the previously published type I hair keratin expression profiles suggested specific, but more likely, random keratin-pairing principles during trichocyte differentiation, and a two-dimensional compilation of the presently known human keratins is presented.
Keratins as markers of malignancy in mouse epidermal tumors.
TLDR
Two-dimensional gels of the keratin polypeptides of normal epidermis and of benign tumors exhibited spot patterns which could be divided at the 61,000 dalton level into an essentially basic subgroup, comprising the high molecular weight keratins, and an acidic subgroup including the low molecular weight components.
Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes*
TLDR
Evolutionary tree construction reveals an early divergence of hair keratin genes from cytokeratin genes, followed by the segregation of the genes into the three subclusters of tandemly arranged genes.
Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs.
A keratin set which consists of a type I 47kd and a type II 57kd protein occurs as a major constituent of the keratin patterns of various internal stratified epithelia of the mouse. We have isolated
The keratins of the human beard hair medulla: the riddle in the middle.
TLDR
Both epithelial and hair keratins behave highly promiscuously with regard to heterodimer- and IF formation, which also includes keratin chain interactions in IF bundles.
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