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Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up
Background Three large randomised trials have shown that screening for colorectal cancer (CRC) using the faecal occult blood test (FOBt) can reduce the mortality from this disease. The largest ofExpand
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Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
The British Society of Gastroenterology (BSG) and the Association of Coloproctology for Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The aim, as before, is toExpand
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Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis
Many colorectal tumors lose or downregulate cell surface expression of MHC class I molecules conferring resistance to T‐cell‐mediated attack. It has been suggested that this phenomenon is due to inExpand
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Effect of faecal occult blood screening on mortality from colorectal cancer: results from a randomised controlled trial
Background: Three large randomised trials have shown that screening for colorectal cancer using faecal occult blood (FOB) tests can reduce the mortality from this disease. Two national pilot studiesExpand
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Glyceryl trinitrate is an effective treatment for anal fissure
PURPOSE: It has been suggested that chronic anal fissure is ischemic in origin because of poor blood supply and spasm of the internal anal sphincter. Nitric oxide donors such as glyceryl trinitrateExpand
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Prevalence of anal human papillomavirus infection and intraepithelial neoplasia in renal allograft recipients
A study was performed to test the hypothesis that renal allograft recipients are at high risk of developing anal human papillomavirus (HPV) infection and anal intraepithelial neoplasia (AIN). A totalExpand
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Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer
Objective To evaluate immunosurveillance/editing in colorectal cancer. Design Transformation stimulates the production of interferon γ (IFNγ) which signals via the IFNγ receptor (IFNGR1) on tumours.Expand
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Use of glyceryl trinitrate ointment in the treatment of anal fissure
Anal fissure is often treated surgically by sphincterotomy. There is growing concern over the effects of this procedure on continence. Nitric oxide donors such as glyceryl trinitrate are thought toExpand
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Overexpression of FLIPL Is an Independent Marker of Poor Prognosis in Colorectal Cancer Patients
Purpose: Colorectal cancer is one of the most common cancers. The tumor necrosis factor–related apoptosis inducing ligand (TRAIL) pathway transmits apoptotic signals and anticancer agents thatExpand
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Faecal calprotectin levels in a high risk population for colorectal neoplasia
BACKGROUND Faecal concentrations of the protein calprotectin have been found to be elevated in patients with colorectal neoplasia, suggesting that it might be used as a screening tool for colorectalExpand
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