• Publications
  • Influence
European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis
Crohn’s disease (CD( is a lifelong disease arising from an interaction between genetic and environmental factors, but seen predominantly in the developed countries of the world. The precise aetiologyExpand
  • 394
  • 19
  • PDF
Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients.
OBJECTIVE In this study we describe clinical and immunogenetic findings in 62 unselected patients with relapsing polychondritis. METHODS In a multicenter study, clinical data of 26 (41.9%) femaleExpand
  • 220
  • 19
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.
Single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene resulting in a diminished nuclear factor-kappaB (NF-kappaB) response to bacterial cell wall products have been associated with anExpand
  • 267
  • 18
  • PDF
A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease.
WILLIAM J. SANDBORN,*,‡ BRIAN G. FEAGAN,§ STEPHEN B. HANAUER,*,‡ HERBERT LOCHS,* ROBERT LOFBERG,* ROBERT MODIGLIANI,*,\ DANIEL H. PRESENT,*,‡ PAUL RUTGEERTS,* JURGEN SCHOLMERICH,* EDUARD F. STANGE,*Expand
  • 569
  • 17
Fatty acid‐induced induction of Toll‐like receptor‐4/nuclear factor‐κB pathway in adipocytes links nutritional signalling with innate immunity
To study the effects of fatty acids and the involvement of the Toll‐like receptor‐4/nuclear factor‐κB (TLR‐4/NF‐κB) pathway with respect to the secretion of adipokines from adipocytes 3T3‐L1Expand
  • 302
  • 15
Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.
Genomic structure, promoter region, amino acid sequence and exon-specific primer combinations of the human omentin gene are presented. Omentin mRNA expression differs between omental adipose tissueExpand
  • 276
  • 13
Wound healing and fibrosis in intestinal disease
The mechanisms of wound healing in general have gained interest in recent years, as it has become obvious that the tightly regulated process of tissue repair and regeneration is of great importanceExpand
  • 213
  • 12
Comparison of magnetic resonance imaging colonography with conventional colonoscopy for the assessment of intestinal inflammation in patients with inflammatory bowel disease: a feasibility study
Aim: Magnetic resonance imaging (MRI) based colonography represents a new imaging tool which has mainly been investigated for polyp screening. To evaluate this approach for patients with inflammatoryExpand
  • 122
  • 12
  • PDF
Ischemic-Like Cholangiopathy With Secondary Sclerosing Cholangitis in Critically Ill Patients
OBJECTIVES:Sclerosing cholangitis in critically ill patients (SC-CIP) is a newly described entity of severe biliary disease with progression to liver cirrhosis. The mechanisms leading to this form ofExpand
  • 109
  • 12
Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study.
PURPOSE To evaluate in patients with advanced colorectal cancer (CRC) three treatment regimens of oral capecitabine in order to select the most appropriate regimen for testing in phase III. Expand
  • 323
  • 11