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Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Observations indicate that adenosine mediates the effects of acupuncture and that interfering withAdenosine metabolism may prolong the clinical benefit of acupuncture. Expand
Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors
A1AR null mutant mice are a promising tool to study the functional role of A1AR in different target tissues and suggest that adenosine is a required constituent of the juxtaglomerular signaling pathway. Expand
Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.
A role for vascular PPARgamma as a peripheral factor participating in regulation of cardiovascular rhythms is uncovered, and ChIP and promoter assays revealed that Bmal1 is a direct PPargamma target gene. Expand
Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity. Expand
Localization of bumetanide- and thiazide-sensitive Na-K-Cl cotransporters along the rat nephron.
Differential nephron localization of NKCC2 isoforms suggests that Na-K-Cl cotransporters may differ in their transport characteristics to explain regulation of salt transport along the nephrons. Expand
Regulation of cyclooxygenase expression in the kidney by dietary salt intake.
Divergent regulation of COX-2 in cortex and medulla by dietary salt suggests that prostaglandins in different kidney regions serve different functions, with medullary production playing a role in promoting the excretion of salt and water in volume overload, whereas cortical prostag landins may protect glomerular circulation in volume depletion. Expand
A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple Sclerosis
Modulation of neuroinflammation by the A1AR represents a novel mechanism that provides new therapeutic opportunities for MS and other demyelinating diseases. Expand
A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.
  • J. Li, C. Chou, +7 authors J. Wess
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1 October 2009
Both acute and chronic treatment of the mutant mice in which the V2R gene could be conditionally deleted during adulthood by administration of 4-OH-tamoxifen greatly reduced all major manifestations of XNDI, including changes in renal morphology. Expand
Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance.
It is suggested that different NKCC2 splice variants cooperate in salt retrieval along the TAL and that the coexpression of two splICE variants in the macula densa cells facilitates efficient salt sensing over wide ranges of fluctuating salt concentrations. Expand
Low Chloride Stimulation of Prostaglandin E2Release and Cyclooxygenase-2 Expression in a Mouse Macula Densa Cell Line*
It is concluded that low chloride stimulates PGE2 release and COX-2 expression in MMDD1 cells through activation of MAP kinases. Expand